摘要
[目的]评价有夜间症状的胃食管反流病(GERD)患者使用PPI+H2RA的联合治疗与PPI单药治疗在提高患者生存质量方面的影响。[方法]107例经内镜确诊的GERD患者随机接受8周的奥美拉唑20mg/次,2次/d联合雷尼替丁150mg/次,2次/d治疗(54例)或接受奥美拉唑20mg/次,2次/d单药治疗(53例)。主要终点是8周后健康调查量表(SF-36)各维度评分。[结果]99例合格受试者完成了8周治疗,联合用药组50例,PPI单药组49例。治疗8周后,2组SF-36各维度得分均显著提高(P<0.05)。与PPI单药组比较,联合用药组的生理功能、生理职能、躯体疼痛、活力评分增加更明显(P<0.05);社会职能、情感职能、精神健康、总体健康评分增加量组间差异无统计学意义。[结论]与PPI单药治疗比较,为期8周的PPI+H2RA联合用药在一定程度上能更好改善有夜间症状GERD患者的生理功能、生理职能、躯体疼痛、活力方面的生存质量,而在社会职能、情感职能、精神健康、总体健康方面差异无统计学意义。
[Objective]To compare PPI ＋ H2RA combination therapy with PPI monotherpy to improve living quality in GERD subjects with night symptoms.[Methods]Total of 107 GERD subjects with night symptoms,diagnosed by endoscopy,were randomized to receive omeprazole 20 mg bid plus ranitidine 150 mg bid（n=54）or to receive omeprazole 20 mg bid（n =53）for 8 weeks.The outcomes were assessed with the Medical Outcomes Study Short-Form 36 Health Survey （SF-36）.[Results] In all,99 eligible subjects have completed treatment for 8 weeks,50 subjects in PPI＋ H2RA group and 49 subjects in PPI group.The scores of each domain of SF-36 of both group were increased（P〈0.05）after 8 weeks.Compared with PPI group,the scores of combination therapy group increased significantly in physical functioning,role-physical,bodily pain,vitality （P 〈0.05） after 8 weeks,but not in social functioning,role-emotional,mental health,general health.[Conclusion]Compared PPI monotherpy,the treatment of proton pump inhibitors （PPI） plus H2-receptor antagonists（H2 RA）for 8 weeks could better improve physical functioning,rolephysical,bodily pain,vitality but not in social functioning,role-emotional,mental health,general health in treating GERD subjects with night sympyoms.
出处
《中国中西医结合消化杂志》
CAS
2014年第12期710-713,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
胃食管反流病
生存质量
联合治疗
GERD with night symptoms
living quality
combination therapy
