摘要
目的:明确兰索拉唑药理和毒理作用特点,为其临床用药提供参考。方法:通过对近十几年来兰索拉唑国内外相关文献进行整理、归纳与分析,综述兰索拉唑的构效特点、对消化系统的药理作用及对机体产生的毒理作用。结果:兰索拉唑具有保护胃黏膜、抑制溃疡形成、促进溃疡愈合、抗幽门螺杆菌等药理作用;毒理学研究表明兰索拉唑有潜在致癌风险。结论:应在观察上市后的兰索拉唑用药风险的基础上,进一步深入研究其毒理学特点和药物之间的相互作用,以便为临床不良反应发生作出合理解释和寻找有效解决办法,确保兰索拉唑临床用药的安全性、合理性和高效性。
Objective：To explore the pharmacological effects and toxicological infonnations of lansoprazole and provide the usage of application lansoprazole for clinic. Methods： Literatures in latest decades both at home and abroad about lansoprazole were collated, an- alyzed and summarized to summarize the characteristics of structure-activity, pharmacological effects on digestive system and toxic reac- tions. Results： As a commonly used proton-pump inhibitor, lansoprazole has the effects of protecting gastric mucosa, inhibiting exulcer- ation, promoting its healing and eradicate Helicobacter pylori. However, lansoprazole had the potential of being carcinogenic. Conclusion ： The toxicity characteristics of lansoprazole and interaction with other medicine need to be further more researches on the ba- sis of surveying lansoprazole-induced risks to explain the adverse reactions in chnic and explore the effective methods, which will ensure the safety, rationality and validity of lansoprazole.
出处
《中国药物评价》
2014年第6期378-380,384,共4页
Chinese Journal of Drug Evaluation
基金
国家重大新药创制科技重大专项课题:中药复方药理学研究及药效学评价关键技术(2009ZX09502-015)
注射用兰索拉唑技术升级及增加临床适应证的研究(2014ZX09201-003-001)
