摘要
目的：观察髓芯减压植骨干细胞移植结合股骨头坏死愈胶囊治疗早期股骨头坏死的近期临床疗效。方法：采用髓芯减压植骨干细胞移植治疗早期股骨头坏死患者33例（39髋）。以Harris评分和术后X线、MRI评价为标准,评价评分变化、有无进展及坏死面积变化。结果：术后随访,33例（39髋）获得12~24个月随访,平均（19.6±2.7）个月。术后切口均Ⅰ期愈合,无感染等并发症发生。术前Harris评分为（59.7±5.2）分,术后12个月为（82.0±5.6）分,术后12个月Harris评分较术前显著改善（P〈0.05）,按照Harris评分标准：优良率为87.2%。X线检查2例2髋ⅡC期患者术后2年发展为Ⅲ期塌陷,进展率为5.1%,MRI测得坏死面积百分比,术前为（30.3±2.7）%,术后12个月为（16.4±3.0）%。结论：髓芯减压植骨干细胞移植结合股骨头坏死愈胶囊口服治疗早期股骨头坏死的近期临床疗效安全可靠,适用于ARCO分期Ⅰ期及ⅡA、ⅡB期患者。
Objective： To observe the early clinical outcome of core decompression combined with implantation of autolognus bone marrow stem cells and gugutou huaisiyu capsule at early stage osteonecrosis of femoral head. Methods： Core decompression combined with implantation of autologous bone marrow stem cells and gugutou huaisiyu capsule was applied to treat 33 cases of panic,ors with early stage osteonecrosis of femoral head in 39 hips; The score change was evaluated and the necrotic area with Harris score and the post-operation X-ray and MRI were observed as the standard. Results： The 33 cases （39 hips） got 12-24 months follow-up, with average of（19.6±2.7） months. Ineislons in the group got healing by first intention without such complications as infection. The Harris scores of patients increased significantly from （59.7±5.2） to （82.0±5.6） points （P〈0.O5）.The rate of excellent and good results was 87.2%. In X-ray, 2 hips had aggravated to femoral head collapse as stage HI; The average percentage of necrotic area diminished significantly from（30.3 ±2.7）% to（16.4±3.0）%, in MRI. Conclusion： Core decompression combined with implantation of autologous bone marrow stem eells and gugutou huaisiyu capsule is a safe and effective treatment foe early stage osteoneerosis of the femoral head, especially for ARCO stage I and Ⅱ A, Ⅱ B patients.
出处
《中医药导报》
2015年第3期8-10,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
河南省公益类科研院所预研项目(09yy0068)
关键词
髓芯减压
干细胞移植
股骨头坏死
股骨头坏死愈胶囊
core decompression
cell transplantation
Femoral head necrosis
Gugutou Huaisiyu Capsule
