摘要
目的观察天麻钩藤饮加减对妊娠期高血压疾病(HDCP)患者RSS系统的影响。方法将160例HDCP患者随机分为治疗组和对照组各80例。对照组给予硫酸镁注射液静脉滴注;治疗组在硫酸镁注射液治疗基础上加用天麻钩藤饮加减治疗。于两组治疗前和治疗72 h后比较血压、24 h尿蛋白定量及血清肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)水平变化。结果两组治疗后收缩压和舒张压与治疗前比较均明显下降,差异均有统计学意义(P<0.01)。治疗后,治疗组收缩压和舒张压显著优于对照组,与对照组比较差异具有统计学意义(P<0.01)。两组治疗后24 h尿蛋白定量与治疗前比较均明显下降,差异均有统计学意义(P<0.01)。治疗后,治疗组24 h尿蛋白定量显著优于对照组(P<0.01)。治疗后,治疗组血清肾素活性(PRA)和血管紧张素Ⅱ(AngⅡ)下降明显(P<0.01)。结论在硫酸镁解痉药物治疗基础上应用天麻钩藤饮加减治疗HDCP能够显著改善患者血压和24 h尿蛋白定量,其作用可能与降低血清PRA和AngⅡ水平有关。
Objective： To investigate the effect of Tianmagouteng Decoction on RSS system in patients with hypertensive disorder complicating pregnancy（HDCP）. Methods： 160 HDCP cases were randomly divided into the control group and the observation group with 80 cases in each group. The control group was given Magnesium sulfate injection therapy and the observation group was given Magnesium sulfate injection combined Tianmagouteng Decoction. Levels including the blood pressure,the 24 hours urinary protein excretion,the serum renin activity and the Ang Ⅱwere compared before and after 72 hours treatment. Results： The systolic blood pressure and diastolic blood pressure were significantly lower than those in the control group after 72 hours treatment.There was a statistical difference about the intra-group comparision of systolic and diastolic pressures in both groups（P〈0.01）. The effect of reducing blood pressure in the observation group was significantly better than that in the control group（P〈0.01）. The 24 hours urinary protein excretion were significantly lower than that in the control group after 72 hours treatment,The intra-group comparision of 24 hours urinary protein excretion had significant differences in both groups（P〈0.01）. The serum renin activity and AngⅡ were significantly lower than those in the control group after 72 hours treatment,The intra-group comparision of serum renin activity and AngⅡ had significant differences in both groups（P〈0.01）. Conclusion： The pressure and 24 hours urinary protein excretion has a remarkable improvement with Magnesium sulfate injection combined Tianmagouteng Decoction on patients with hypertensive disorder complicating pregnancy. It may be connected with reducing the serum renin activity and AngⅡ level.
出处
《中国中医急症》
2015年第1期145-146,共2页
Journal of Emergency in Traditional Chinese Medicine
基金
广东省深圳市宝安区科技计划-社会公益立项资助项目(2012256)
关键词
妊娠期高血压疾病
天麻钩藤饮
肾素
血管紧张素Ⅱ
Hypertensive disorder complicating pregnancy
Tianmagouteng Decoction
Renin activity
AngⅡ
