摘要
目的观察活血化瘀药物三七总皂苷短期应用对强直性脊柱炎病情活动的影响。方法回顾性分析2012年5月—2014年5月收治的强直性脊柱炎42例,分为对照组23例和活血组19例。对照组应用常规治疗,活血组在常规治疗基础上加用活血化瘀药物血栓通,分别于入院、出院时监测红细胞沉降率(ESR)、超敏C反应蛋白(hsCRP)及血小板计数(PLT)、Bath强直性脊柱炎病情活动指数(BASDAI)、Bath强直性脊柱炎功能指数(BASFI)、Bath强直性脊柱炎计量指数(BASMI)、患者整体评价(PG)、夜间痛视觉模拟评分(VAS)及基于hs-CRP的强直性脊柱炎疾病活动度评分(ASDAS)的具体数值。结果活血组的hs-CRP、PLT、BASDAI、夜间痛VAS及BASMI数值治疗后有较大幅度下降(P<0.05),hs-CRP、BASDAI、夜间痛VAS与对照组治疗后相比差异有统计学意义(P<0.05);两组治疗前后BASFI、ASDAS、PG评分比较,差异均有统计学意义(P<0.05);与对照组治疗后比较,活血组ASDAS有统计学意义(P<0.05);ASAS 20达标率两组间差异有统计学意义(P<0.05)。结论应用活血化瘀药物三七总皂苷联合常规疗法或提高强直性脊柱炎的临床疗效。
Objective To investigate the effect of short-term administration of Panax Notoginsenosidum（ PNS）,a drug for invigorating blood circulation and eliminating stasis,on pathogenetic condition of ankylosing spondylitis（ AS）.Methods Clinical data of 42 patients with ankylosing spondylitis during May 2012 and May 2014 was retrospectively analyzed,and the patients were divided into control group（ n = 23） and promoting circulation treatment group（ PNS group,n = 19）. The control group received conventional treatment,while the PNS group was treated with Xueshuantong,a drug for invigorating blood circulation and eliminating stasis,based on the conventional treatment. Erythrocyte sedimentation rate（ ESR）,high-sensitivity C-reactive protein（ hs-CRP） and platelet count（ PLT）,Bath AS disease activity index（ BASDAI）,Bath AS function index（ BASFI）,Bath AS metrology index（ BASMI）,patient global assessment（ PG）,night pain of visual analogue score（ night pain VAS）,values of AS disease activity score（ ASDAS） based on the hs-CRP value on admission and discharge were monitored respectively. Results The values of hs-CRP,PLT,BASDAI,night pain VAS and BASMI after the treatment in PNS group were significantly decreased（ P〈0. 05）,and the differences in hs-CRP,BASDAI and night pain VAS were statistically significant compared with those in control group（ P〈0. 05）. Before and after the treatment,the differences in BASFI,ASDAS and PG scores were statistically significant in the two groups（ P〈0. 05）. Compared with that in the control group after treatment,ASDAS value in PNS group was statistically significant（ P〈0. 05）; ASAS 20 compliance rates between the two groups had statistically significant difference（ P〈0. 05）. Conclusion Administration of promoting blood circulation drugs of Panax Notoginsenosidum combined with conventional treatment may improve the curative effect in treatment of AS.
出处
《解放军医药杂志》
CAS
2015年第1期60-63,68,共5页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
军队中医药专项重点课题(10ZYZ104)
河北省科技计划项目(13277704D)
关键词
活血化瘀
三七总皂苷
脊柱炎
强直性
治疗结果
Blood act stasis remove
Panax notoginsenosidum
Spondylitis
ankylosing
Treatment outcome
