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胆汁及血清TNF-α和IL-6的在急性梗阻性化脓性胆管炎患者中的表达及意义 被引量:7

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摘要 急性梗阻性化脓性胆管炎(AOSC)是因为胆管梗阻及细菌感染,胆管内压升高,肝脏胆血屏障受损,大量细菌及毒素进入血循环,导致以肝胆系统病损为主,合并多器官损伤的全身严重感染性疾病。AOSC时内毒素和脂多糖会刺激巨噬细胞及库普弗细胞产生大量细胞因子,如 TNF-α、IL-6、IL-8、IL-10等;细胞因子再进一步引起机体代谢紊乱,微血管通透性增强,组织血液灌注减少,血液凝固性增高,最终造成多器官功能不全综合征(MODS)甚至死亡。本研究采用我院收治的行 ERC检查治疗的急性梗阻性化脓性胆管炎确诊患者38例作为研究组,同期因反复发作性上腹部疼痛入院行 ERCP检查但未发现化脓性胆管炎病变的受试者38例作为对照组,观察分析两组患者TNF-α、IL-6水平变化,现将结果报告如下。
出处 《中国实验诊断学》 2015年第1期62-64,共3页 Chinese Journal of Laboratory Diagnosis
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同被引文献90

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