摘要
目的探讨用异环磷酰胺（IFO,I）、足叶乙甙（VP-16,E）、长春地辛（VDS,V）、地塞米松（DXM,D）组成的IEVD方案治疗复发和难治非霍奇金淋巴瘤的疗效和不良反应。方法 32例经CHOP方案治疗失败的患者予IEVD方案治疗,IFO 1.2g·m^-2·d^-1,静脉滴注,d1-5,IFO后配合美司那每次400mg,0h、4h、8h静脉推注3次;VP-16 80mg·m^-2·d^-1,静脉滴注,d1-3;VDS 3mg·m^-2·d^-1,静脉注射,d1,8;DXM 20mg/d,静脉滴注,d1-5,平均每28天为1周期,化疗2个周期后进行疗效评价,有效者继续化疗4个周期,无效者更改治疗方案。结果 32例患者接受IEVD方案化疗,完全缓解（CR）10例,未经确认的完全缓解（CRu）2例,部分缓解（PR）9例,总有效率65.6%,中位缓解期为8个月,1年生存率78.1%（25/32）,不良反应主要为骨髓抑制、恶心呕吐和脱发。结论 IEVD方案是治疗复发或难治非霍奇金淋巴瘤的有效方案,不良反应可耐受。
Objective To investigate the efficacy and adverse reactions of IEVD regimen composed of ifos‐famide （IFO ,I） ,etoposide （VP‐16 ,E） ,vindesine （VDS ,V） ,dexamethasone （DXM ,D） in treating recurrent and re‐fractory non‐Hodgkin′s lymphoma（NHL） .Methods 32 cases of NHL with failure by CHOP regimen were given with IEVD regimen ,IFO 1 .2 g·m^-2 ·d^-1 ,by intravenous drip on 1-5 d ,then combined with mesna 400 mg by in‐travenous injection for 3 times at 0 ,4 ,8 h;VP‐16 80 mg·m^ -2 ·d^-1 ,by intravenous drip on 1-3 d;VDS 3 mg·m ^-2·d^-1 ,by intravenous injection on 1 ,8 d;DXM 20 mg/d ,by intravenous drip on 1-5 d ,with 28 d as one circle .The efficacy was evaluated after 2 treatment circles .The effective patients were continuously treated for 4 cycles of chem‐otherapy ,and the ineffective patients were treated with regimens else .Results In 32 cases treated by IEVD regimen , 10 cases were complete remission （CR） ,2 cases were complete remission unconfirmed （CRu） ,9 cases were partial re‐mission （PR） ,with the total effective rate of 65 .6% .The median duration of remission was 8 months ,and the 1‐year survival rate was 78 .1% （25/32） .The adverse reactions were mainly myelosuppression ,nausea ,vomiting and hair loss .Conclusion The IEVD regimen is an effective regimen in the treatment of recurrent and refractory NHL with tolerable adverse reactions .
出处
《检验医学与临床》
CAS
2015年第2期179-181,共3页
Laboratory Medicine and Clinic
