摘要
目的探讨降钙素原(PCT)与超敏C反应蛋白(hs-CRP)联合检测对儿童中枢神经系统感染性疾病的临床意义。方法检测43例化脓性脑膜炎、43例病毒性脑膜炎患儿及43例健康儿童血清PCT及hs-CRP水平,并进行对比分析。结果病毒性脑膜炎组治疗前、治疗后PCT及hs-CRP与健康对照组比较差异无统计学意义(P>0.05),且治疗前后未见明显变化(P>0.05);化脓性脑膜炎组治疗前PCT、hs-CRP水平均明显高于病毒性脑膜炎组及健康对照组(P<0.05),治疗后均明显低于治疗前(P<0.05),治疗后PCT、hs-CRP与病毒性脑膜炎组及健康对照组比较差异有统计学意义(P>0.05)。结论 PCT与hs-CRP联合检测对于化脓性脑膜炎与病毒性脑膜炎的鉴别诊断,以及化脓性脑膜炎治疗效果的判断和预后的评估均具有重要临床意义。
Objective To explore the clinical value of combined detection of procalcitonin （PCT） and high sensitivity C-reactive protein （hs-CRP）in children with central nervous system infection. Methods PCT and hs-CRP were detected and compared in 43 children with purulent meningitis, 43 children with viral encephalitis, and 43 healthy children. Results There were no significant differences on the levels of PCT and hs-CRP between the viral encephalitis group before and after therapy and the healthy group （P〉0.05） ,and no significant change found in the viral encephalitis group before and after treatment（P〉0.05）. The levels of PCT and hs-CRP in the purulent meningitis group were significant higher than those in the other two groups before treatment （P〈 0.05） ,which after treatment were also significant lower than those before treatment（P〈0.05） ,but no significant differences were found between the purulent meningitis group after treatment and the healthy group （P〉0.05）. Conclusion Joint detection of PCT and hs-CRP has important significance in differential diagnosis of purulent meningitis and viral encephalitis,the determine of the ef- ficacy and assessment of prognosis of purulent meningitis.
出处
《国际检验医学杂志》
CAS
2015年第2期209-210,共2页
International Journal of Laboratory Medicine
关键词
降钙素原
超敏C反应蛋白
儿童
中枢神经系统
procalcitonin
high sensitivity C-reactive protein
children
central nervous system
