摘要
目的分析他唑巴坦/哌拉西林临床给药方案的改变对临床疗效的影响,寻找最合适、最有效的给药方案。方法随机选取我院外科2013年1-12月收治的60例感染患者,随机分为2组,对照组采用常规给药方案:他唑巴坦/哌拉西林4.5 g,静脉滴注,1次/6 h,每次输注时间控制为30 min;观察组采用延长给药时间方案:他唑巴坦/哌拉西林4.5 g,静脉泵入滴注,1次/6 h,每次用输液泵控制输注时间为60 min。观察两组患者的临床疗效(C反应蛋白,CRP)、不良反应和住院时间。结果观察组的CRP明显低于对照组(P<0.05);观察组的治疗总有效率明显高于对照组(P<0.05);观察组的不良反应率明显低于对照组(P<0.05),观察组的住院时间明显短于对照组(P<0.05)。结论改变给药方案,延长给药时间,可以提高临床疗效,减少不良反应发生率,缩短住院时间,能够有效缓解患者痛苦,帮助患者减轻经济负担,值得临床推荐使用。
Objective To study the impact of changing tazobactam /piperacillin＇s clinical dose regimens on clinical efficacy,and find the most appropriate and effective drug regimens. Methods Sixty infection patients of Surgical Department in our hospital from January to December in 2013 were randomly divided into two groups,control group was treated with routine regimen： tazobactam / piperacillin 4. 5 g,intravenous drip,once every 6 hours,each infusion time controlled for 30 min; observation group was extended the delivery time： tazobactam / piperacillin 4. 5 g,intravenous drip,once every 6 hours,with an infusion pump to control the infusion time for 60 min. The clinical efficacy（ Creactive protein）,adverse reaction,and the hospitalization time of the two groups was observed. Results C-reactive protein of observation group was lower than that of control group（ P〈0. 05）; the total effective rate of observation group was significantly higher than that of control group（ P〈0. 05）; adverse reactions of observation group were significantly lower than those of control group（ P〈0. 05）,the hospitalization time of observation group was shorter than that of control group（ P〈0. 05）. Conclusion Change dose regimens and extend the delivery time,can improve the clinical efficacy,reduce the adverse reaction rate,shorten the hospitalization time,and alleviate the suffering of patients effectively,help patients to reduce the economic burden,it is worthy of recommending in clinic.
出处
《实用药物与临床》
CAS
2015年第1期36-38,共3页
Practical Pharmacy and Clinical Remedies
