摘要
目的探讨TNF-α、IL-8、IFN-γ在脓毒症病理过程作用及临床意义。方法对脓毒症患儿50例,分别测定确诊脓毒症后0h、24h、48h、72h外周血TNF-α,IL-8、IFN-γ含量和简化危重评分PCIS。结果 TNF-α、IL-8、IFN-γ在0h、24h、48h、72h时间点上的含量逐渐降低,组内两两比较差异有统计学意义。PCIS T2、T3、T4提高显著,差异有统计学意义。结论 TNF-α、IL-8、IFN-γ可作为诊断脓毒症的辅助指标,同时也可作为判断脓毒症治疗效果的指标。
Objective To investigate the changes of TNF-α, IL-8and FN-γ levels in children with sepsis. Methods 50 children with sepsis were assessed with TNF-α, IL-8, IFN-γand PCIS at the 0h, 24h, 48h and 72h after children with sepsis were confirmed. Results TNF-α, IL-8and FN-γ levels Gradually decreased over time, there were significant difference. Conclusion TNF-α, IL-8and FN-γare considered diagnosis and curative effect of sepsis.
出处
《中国医药科学》
2014年第24期180-182,共3页
China Medicine And Pharmacy
基金
黑龙江省牡丹江市科学技术计划项目(z2013s037)
