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环磷酰胺在原发性IgA肾病治疗中的价值 被引量：5

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摘要 原发性IgA肾病（IgA nephropathy,IgAN）是以肾小球系膜区IgA沉积为特征的肾小球肾炎,是我国最常见的原发性肾小球疾病。据报道,我国IgAN占原发性肾小球肾炎的比例为45.3%-58.2%[1,2],IgAN患者的5年肾脏存活率为85.1%,10年为77.1%[3]。目前IgAN的病因尚不清楚,发病机制尚未阐明。
作者 李灏 王伟铭
机构地区 上海交通大学医学院附属瑞金医院肾脏科
出处 《中国中西医结合肾病杂志》 2014年第11期1012-1014,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 国家自然科学基金资助项目(No.81270782 30771000) 国家重点基础研究发展计划项目(973计划)(No.2012CB517700) 科技部"十二五"科技攻关项目(No.2011BAI10B00)
关键词 肾病治疗 IgA肾病 新月体 肾小球系膜 肾病综合征型 尿蛋白 霉酚酸酯 系膜增生性 肾活检 局灶节段
分类号 R692.31 [医药卫生—泌尿科学]
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参考文献19

  • 1Li LS,Liu ZH. Epidemiologic data of renal diseases from a single unit in China: analysis based on 13,519 renal biopsies. Kidney Int,2004, Sep,66 ( 3 ) :920 - 923.
  • 2Zhou FD, Zhao MH, Zou WZ, et al. The changing spectrum of primary glomerular diseases within 15 years : a survey of 3331 pa- tients in a single Chinese center. Nephrol Dial Transplant,2009, 24 (3) : 870 - 876.
  • 3Lv J, Zhang H, Zhou Y, et al. Natural history of immunoglobulin A nephropathy and predictive factors of prognosis: a long - term follow up of 204 cases in China. Nephrology ( Carlton), 2008, Jun,13(3) :242 -246.
  • 4KDIGO. KDIGO clinical practice guideline for glomerulonephritis [ EB/OL] [2012 - 01 - 22]. http://www, kidney - internation- al. org.
  • 5Roccatello D, Ferro M, Cesano G, et al. Steroid and cyclophos- phamide in IgA nephmpathy. Nephrol Dial Transplant, 2000, 15 (6) :833 -835.
  • 6Tumlin JA, Lohavichan V, Hennigar R. Crescentic, proliferative IgA nephropathy: clinical and histological response to methyl- prednisolone and intravenous eyelophosphamide. Nephrol Dial Transplant ,2003,18 (7) : 1321 - 1329.
  • 7Melntyre CW, Fluek R J, l.ambie SH. Steroid and cyclophospha-mide therapy for IgA nephropathy associated with crescentic change:an effective treatment. Clin Nephrol,2001,56 (3) :193 - 198.
  • 8Chen KJ, Cheng CH, Wu M J, et al. Effect of corticosteroid and cyclophosphamide in IgA nephropathy patients with heavy pro- teinuria and/or moderate - severe pathological changes. J Chin Med Assoc ,2003 ,66 (5) :263 - 270.
  • 9Rasic S, Uncanin S, Aganovic K, et at. Treatment of IgA nephrop- athy of adults presented by nephrotic syndrome. Bosn J Basic Med Sci,2008,8(3) :230 -233.
  • 10李娅,王伟铭,任红,张文,沈平雁,王朝晖,李晓,贾晓媛,陈楠.沷尼松联合环磷酰胺治疗免疫球蛋白A肾病伴肾病综合征和肾功能不全[J].上海医学,2012,35(9):746-750. 被引量：36

二级参考文献32

  • 1Lai KN.Recent advances in IgA Nephmpathy:World Scientific:2008:9-19.
  • 2Li LS,Liu ZH.Epidemiologic data of renal diseases from a single unit in China:analysis based on 13,519 renal biopsies.Kidney Int,2004,66(3):920-923.
  • 3Geddes CC,Rauta V,-Gronhagen-Risks C,et al.A tricontinental view of IgA nephropathy.Nephrol Dial Transplant,2003,18(8):1541-1548.
  • 4D'Amico G.Natural history of idiopathic IgA nephropathy and factors predictive of disease outcome.Semin Nephrol,2004,24(3),179-196.
  • 5Coppo R,D'Amico G.Factors predicting progression of IgA nephropathies.J Nephrol,2005,18(5):503-512.
  • 6Goto M,Wakai K,Kawamura T,et al.A scoring system to predict renal outcome in IgA nephropathy:a nationwide 10-year prospective cohort study.Nephrol Dial Transplant,2009,24(10):3068-3074.
  • 7Reich HN,Troyanov S,Scholey JW,et al.Remission of proteinuria improves prognosis in IgA nephropathy.J Am Soc Nephrol,2007,18(12):3177-3183.
  • 8Li PK,Ho KK,Szeto CC,et al.Prognostic indicators of IgA nephropathy in the Chinese-clinical and pathological perspectives.Nephrol Dial Transplant,2002,17(1):64-69.
  • 9Radford MG,J,Donadio JV,Jr,Bergstrath EJ,et al.Predicting renal outcome in IgA nephropathy.J Am Soc Nephrol,1997,8(2):199-207.
  • 10Berthoux F,Mohey H,Laurent B,et al.Predicting the Risk for Dialysis or Death in IgA Nephmpathy.J Am Soc Nephrol,2011,22(4):752-761.

共引文献120

同被引文献29

引证文献5

二级引证文献17

中国中西医结合肾病杂志
2014年 第11期

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