摘要
以甲酰胺和氯丙酮等为原料合成了离子液体4-甲基-3-丁基噻唑硫酸氢盐。以aldol反应为探针,探究了离子液体催化苯甲醛与丙酮的缩合反应,并对催化剂用量、醛酮比、反应时间和催化剂重复利用等进行了考察。优化工艺条件为:n(苯甲醛)∶n(丙酮)=1.0∶1.8,催化剂用量3%(n/n),反应时间1.5 h,苄叉丙酮的收率达81.2%,催化剂重复使用5次仍可保持较高催化效果。
4-Methyl-3-butylthiazole bisulfate was synthesized from formamide. This acidic ionic liquid was used as the catalyst for aldol reaction. The amount of catalyst, the aldehyde/ketone ratio, the reaction time and the reproducibility of catalytic ability were studied on the condensation reaction between benzaldehyde and acetone. Best result with 81.2% yield was obtained under the conditions of aldehydes/ketones ratio of 1.0：1.8, the amount of catalyst of 3% and the reaction time of 1.5 hrs. The catalyst can be reused for 5 times.
出处
《精细化工中间体》
CAS
2014年第6期52-54,共3页
Fine Chemical Intermediates
基金
浙江省教育厅科研项目(Y200909511)
浙江省教育厅科研项目(Y201122555)
宁波市自然科学基金项目(2014A610210)
浙江医药高等专科学校校级课题(ZPCSR2011006)资助
