摘要
目的:观察补通膏联合舒利迭对慢性持续期支气管哮喘患者肺功能和免疫功能的影响。方法:于立冬前后15 d,将105例患者随机分为3组:联合组、膏方组和舒利迭组。联合组:予补通膏早晚各10 m L+舒利迭(50/250)早晚各1吸。膏方组:予补通膏早晚各10 m L。舒利迭组:予舒利迭(50/250)早晚各1吸。疗程3个月。测定治疗前、治疗结束后、治疗结束3个月后3组患者哮喘控制测试(ACT)评分表得分情况,治疗前后3组患者第1秒用力呼气容积占预计值百分比(FEV1%),血清干扰素-γ(INF-γ),白细胞介素4(IL-4)水平。结果:治疗结束后及治疗结束3个月后ACT评分比较,联合组均高于其余两组(P<0.05);治疗后FEV1%、血清INF-γ比较,联合组均高于其余两组(P<0.05);治疗后IL-4比较,联合组低于其余两组(P<0.05)。结论:补通膏治疗支气管哮喘的机制涉及IL-4,INF-γ等多方面。该研究亦说明,补通膏与舒利迭有协同作用,可有效改善肺功能,调节免疫功能,值得推广应用。
Objective ： To observe the effects of Butong paste （ BT paste） combined with seretide on the lung function and immunologic function in patients with persistent asthma. Method： Before and after 15 days of the fortnightly periods of ＇Beginning of Winter＇, 105 patients were randomly divided into 3 groups： the combination group, the BT paste group and the seretide group. Patients in the BT paste group received 10 mL BT paste, patients in the seretide group received seretide （50/250） , and patients in the combination group received above two treatments each morning and evening for 3 months. Before and after treatment, asthma control test （ACT） values of three groups were observed, the levels of the first second forced expiratory volume percentage of expected value （FEV1%） and serum interferon-γ （INF-γ）, interleukin 4 （IL-4） in serum were measured. Result ： Compared with the other two groups, the levels of ACT value, FEV1% , INF-T in serum were higher （P 〈 0.05 ） , while the levels of IL-4 were lower （P 〈 0. 05 ） in the combination group after treatment. Conclusion ： The mechanisms of BT paste in the treatment of asthma are involved in IL-4, INF-γ and other aspects. The study also shows that the BT paste combined with seretide has synergetic effect, which could improve the lung function and regulate the immunity in treating persistent asthma. This treatment method is worthy of wide application.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2015年第3期172-174,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
河北省中医药管理局科研计划项目(2013043)
