摘要
目的 了解甘肃省武威市城市和农村健康成人碘营养水平及甲状腺功能状态.方法 2009年4月至2010年1月,采用横断面调查方法,在甘肃省武威市城市（城市组）及农村（农村组）常住居民（居住并生活半年以上）中各抽取18～45岁成人约100人,采集1次随机尿样及空腹血样.砷铈催化分光光度法检测尿碘;化学发光免疫法检测血清促甲状腺激素（TSH）、游离甲状腺激素（FT4）、游离三碘腺原氨酸（FT3）;放射免疫法检测血清甲状腺球蛋白抗体（TGAb）、甲状腺微粒体抗体（TMAb）.结果 分别检测城市组、农村组尿样99、98份,尿碘中位数分别为189.0、258.2μg/L,城市组低于农村组（Z=-4.020,P＜ 0.01）.分别检测城市组、农村组血样104、95份,其中城市组FT4[（16.8±3.0）pmol/L]高于农村组[（15.4±2.4）pmol/L,t=3.539,P＜ 0.01].城市组、农村组TGAb阳性率分别为11.5％（12/104）、15.8％（15/95）,TMAb阳性率分别为13.5％ （14/104）、14.7％（14/95）;男、女TGAb阳性率分别为5.5％（6/109）、23.3％（21/90）,TMAb阳性率分别为6.4％（7/109）、23.3％（21/90）,其中TGAb、TMAb阳性率男性均低于女性（X^值分别为13.362、11.661,P均＜0.01）.城市组和农村组甲状腺功能异常率分别为16.3％（17/104）、8.4％（8/95）,其中亚临床型甲状腺功能减退（亚甲减）最常见,分别为14.4％（15/104）、7.4％（7/95）;男、女甲状腺功能异常率分别为11.9％（13/109）、13.3％（12/90）,其中亚甲减分别为11.0％（12/109）、11.1％（10/90）.结论 武威市城市成人碘营养处于适宜水平,但农村存在碘营养偏高或部分过量;甲状腺功能异常发生以亚甲减为主;应关注碘营养过量对患甲状腺疾病,尤其是女性患病的风险.
Objective To study the iodine nutritional status and thyroid function of adults in urban and rural areas of Wuwei City Gansu Province.Methods A cross-sectional survey was performed in 200 adults aged 18-45 who had lived more than six months in Wuwei City from April 2009 to January 2010.A random urine and fasting blood samples were collected.Urinary iodine content was measured with arsenic cerium catalytic spectrophotometry.The thyroid-stimulating hormone （TSH）,free thyroid hormone （FT4） and three free triiodothyronine （FT3） were quantified by direct chemiluminescence immunoassay.Thyroglobulin antibodies （TGAb） and thyroid microsomal antibodies （TMAb） were detected by radioimmunoassay.Results A total of 99 and 98 copies of urine samples of urban and rural groups were tested,respectively.The median of urinary iodine of urban and rural groups was 189.0 and 258.2 μg/L,respectively,and rural group was higher than urban group （Z =-4.020,P 〈 0.01）.A total of 104 and 95 copies of blood samples of urban and rural groups were detected; mean value of FT4 in urban group [（16.8 ± 3.0）pmol/L] was higher than that of rural group [（15.4 ± 2.4）pmol/L,t =3.539,P 〈 0.01].The positive rates of TGAb of urban and rural groups were 11.5% （12/104） and 15.8% （15/95）,respectively; the positive rates of TMAb of urban and rural groups were 13.5% （14/104） and 14.7% （14/95）,respectively; the positive rates of TGAb of male and female were 5.5% （6/109） and 23.3% （21/90）,respectively; the positive rates of TMAb of male and female were 6.4% （7/109） and 23.3% （21/90）,respectively.The positive rates of TGAb and TMAb were lower in male than in female （X^2 =13.362,11.661,all P 〈 0.01）.The rates of thyroid function disorders of urban and rural groups were 16.3% （17/104） and 8.4% （8/95）,of male and female 11.9% （13/109） and 13.3% （12/90）,respectively.Subclinical hypothyroidism in all thyroid function disorders was the most common,which was 14.4% （15/104） and 7.4% （7/95） in urban and rural groups,11.0% （12/109） and 11.1% （10/90） in male and female,respectively.Conclusions Iodine nutrition level is appropriate for adults in urban areas,but in rural areas iodine nutrition is high or excessive; subclinical hypothyroidism in all thyroid function disorders is the most common; we should be concerned about the risk of iodine overdose,especially the risk of illness in women.
出处
《中华地方病学杂志》
CAS
CSCD
北大核心
2015年第1期45-48,共4页
Chinese Journal of Endemiology
基金
“十一五”国家科技支撑计划项目（2006BA106805）
甘肃省卫生行业科研计划管理项目（GWGL2011-3、GWGL2013-58）
关键词
成年人
碘
甲状腺
Adult
Iodine
Thyroid gland
