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协同共刺激分子B7-H4参与肿瘤免疫逃逸的研究进展 被引量：8

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摘要 近年来恶性肿瘤的治疗方法虽然取得了较大进展,但5年生存率仍不理想,寻找新的治疗策略和有效的治疗靶点显得尤为迫切。B7家族是近年来研究较广泛的共刺激分子,其中B7-H4是新近发现的B7家族新成员,对T淋巴细胞介导的免疫应答起重要的负性调节作用。
作者 王利飞 崔澂 刘翠莲 郝淑维
机构地区 河北医科大学第四医院妇产科
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2015年第1期139-141,共3页 Chinese Journal of Immunology
关键词 协同共刺激分子 B7-H4 肿瘤免疫逃逸 负性调节作用 治疗方法 B7家族 5年生存率 恶性肿瘤
分类号 R392 [医药卫生—免疫学]
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参考文献22

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  • 2Sica GL,Choi IH,Zhu G,et al.B7H4,a molecule of the B7 family,negatively T cell immunity[J].Immunity,2003,18(6):849-861.
  • 3Prasad DV,Ricards S,Mal XM,et al.B7S1,a novel B7 family member that negatively regulates T cell activation[J].Immunity,2003,18(6):863-873.
  • 4Zang X,Loke P,Kim J,et al.B7x:a widely expressed B7 familymember that inhibits T cell activation[J].Proc Natl Acad Sci USA,2003,100(18):10388-10392.
  • 5李丽,胡为民,王朝莉,杨致邦.小鼠B7-H4基因的真核表达及其对淋巴细胞增殖的影响[J].中国微生态学杂志,2012,24(4):292-294. 被引量：3
  • 6Park GB,Song H,Kim YS,et al.Cell cycle arrest induced by engagement of B7H4 on Epstein-Barr virus-positive B-cell lymphoma cell lines[J].Immunology,2009,128(3):360-368.
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  • 8Krambeck AE,Thompson RH,Dong H,et al.B7-H4 expression inrenal cell carcinoma and tumor vasculature:associations withcancer progression and survival[J].Proc Natl Acad Sci USA,2006,103(27):10391-10396.
  • 9Tringler B,Liu W,Corral L,et al.B7H4 over expression in ovariantumors[J].Gynecol Oncol,2006,100(1):44-52.
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二级参考文献13

共引文献30

同被引文献78

  • 1SICA GL, CHOI IH, ZHUG, eta1. B7-H4, a molecule 0fthe B7 family, negatively regulates T cell immunity[J]. Immunity, 2003, 18(6): 849-861.
  • 2Choi IH, Zhu G, Sica GL, et al. Genomic organization and expression analysis ofB7-H4, an immune inhibitory molecule of the B7 family. Immunol, 2003, 171(9):4650-4654.
  • 3PRASADDV, RICHARDSS, MAIXM, eta1. B7S1, a novel B7 family member that negatively regulates T cell activation[J].Immunity, 2003, 18(6) : 863-873.
  • 4Zhang L, Wu H, Lu D, et al. The costimulatorymolecule B7-H4 promote tumor progression and ceUproliferation throughtranslocating into nucleus[J]. oncogene, 2013, 32(46) : 5347-5358.
  • 5Krambek A E, Thompson R H, Dong H, et al. B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival[J]. Proc Nad AcadSci USA, 2006, 103(27): 10391-10396.
  • 6Thompson RH, ZangX, Lohse CM, et al. Serum-Soluble B7x is elevated in renal cell carcinoma patients and is associated with advanced stage[J]. CancerRes, 2008, 68(15): 6054-6058.
  • 7Crispen PL, Boorjian SA, Lohse CM, et al. Predictingdisease pmgtmssion after nephrectomy for localized renal cell carcinoma: the utility of prognostic models and molecular biomarkers. Cancer, 2008, 1 13(3) : 450-460.
  • 8JungSG, Chol K U, Lee S D, et al. ThelLelationship between B7-H4 expression andclinicopathologicalcharacteristics in clinical stage T1 conventional renal cell carcinoma[J]. KoreanJUrol,2011, 52(2) : 90-95.
  • 9KREYMBORG K, HAAK S, MURALI R, et al. Ablation of B7-H3 but not BT-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer [ J ]. Cancer immunology re- search ,2015,3 ( 8 ) :849-854.
  • 10NGUYEN A H,MILLER E J,WICHMAN C S,et al. Diagnostic value of tumor antigens in malignant pleural effusion: a meta-analysis[ J]. Transl Res,2015,166(5 ) :432-439.

引证文献8

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中国免疫学杂志
2015年 第1期

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