摘要
目的探讨阿司匹林联合低分子肝素治疗D-二聚体增高复发性流产(RSA)患者的临床效果。方法选取2012年1月—2013年12月在该院妇产科治疗的D-二聚体增高RSA患者。入选患者随机分为三组,安慰剂组64例,阿司匹林组62例,阿司匹林联合低分子肝素组(联合组)60例。比较三组患者的妊娠结局并观察治疗期间不良反应发生情况。结果安慰剂组、阿司匹林组、联合组三组患者的有效率分别为53.1%、67.7%、81.7%,三组患者比较,差异具有统计学意义(χ2=11.46,P=0.003);三组患者在治疗期间发生出血、皮疹、血小板减少、胃肠道反应等不良反应的发生率比较差异无统计学意义(P>0.05)。结论采用阿司匹林联合低分子肝素治疗D-二聚体增高RSA患者能够有效提高活产率,未见明显不良反应发生。
Objective To investigate the clinical effect of aspirin combined with low molecular weight heparin for two D- dimer increased recurrent spontaneous abortion （RSA） patients. Methods D- two dimer increased in RSA patients in author＇s hospital from January 2012 to December 2013 were selected. Patients were divided into 3 groups randomly, 64 patients in the placebo group, 62 patients with aspirin, aspirin and low molecular weight heparin group （combined group） 60 cases. Pregnancy outcomes among three groups of patients were compared and the occurrence of adverse reactions was observed during the treatment period. Results Effective rate of the placebo group, aspirin group, combined group was 53.1%, 67. 7%, 81.7% respectively, the difference among the three groups was statistically significant （x2 = 11.46, P = 0. 003）. The difference adverse reactions in the three groups was no significant differences （P〉0.05）. Conclusion The use of as- pirin combined with low molecular heparin in the treatment of two D- dimer increased in RSA patients can effectively improve the live birth rate, no obvious adverse reactions occurred,
出处
《中国煤炭工业医学杂志》
2015年第2期225-227,共3页
Chinese Journal of Coal Industry Medicine
关键词
阿司匹林
低分子肝素
D-二聚体
复发性流产
Aspirin
Low molecular heparin
D- two dimer
Recurrent spontaneous abortion
