摘要
目的探讨依达拉奉对急性缺血性脑血管病的临床治疗效果,并观察其对患者血清C-反应蛋白(C-reactive protein,CRP)和基质金属蛋白酶-9(matrix metalloproteinases,MMP-9)水平的影响。方法选取2012年5月至2013年12月在该院就诊的急性缺血性脑血管病患者84例,分为观察组和对照组,每组各42例。对照组患者进行抗血小板、调节血压和血脂、降低颅内压、改善微循环等综合治疗,观察组患者在对照组的基础上使用依达拉奉。使用美国国立卫生研究院卒中量表(NIHSS)和日常生活活动能力(ADL)评分对患者治疗前后神经功能和日常生活能力进行评估,并对患者治疗前后CRP和MMP-9水平进行检测,记录治疗过程中发生的不良反应。结果观察组治疗后1周和治疗后2周NIHSS评分和ADL评分与对照组比较,差异具有统计学意义(P<0.05);观察组治疗后1周和治疗后2周CRP和MMP-9与对照组比较,差异具有统计学意义(P<0.05);观察组患者不良反应发生率(7.14%)与对照组比较(4.76%),差异无统计学意义(P>0.05)。结论依达拉奉可提高急性缺血性脑血管病的临床治疗效果,降低血清CRP和MMP-9水平可能参与了其药效调节的机制通路。
Objective To explore the clinical effect of edaravone on acute ischemic cerebrovascular disease ,and to observe its effect on serum C‐reactive protein （CRP） and matrix metalloproteinase‐9（MMP‐9） level .Methods Eighty four patients with acute ischemic cerebral vascular disease who were treated in our hospital during 2012 May to 2013 December were selected and divided in‐to observation group and control group ,with 42 cases in each group .The control group was treated with anti‐platelet ,regulating blood pressure and blood lipid ,reducing intracranial pressure ,improve microcirculation and other comprehensive treatment ;the pa‐tients in observation group were treated with increased dose of edaravone on the basis of the control group .America national institu‐tes of health stroke scale（NIHSS） and activities of daily living scale （ADL） were used to evaluate the neurological function and ac‐tivities of daily living ability of patients before and after the treatment ,the CRP and MMP‐9 level were detected before and after treatment ,and the adverse reaction during the treatment was recorded .Results After one week and two weeks after treatment , there were significant differences between treatment group and control group in the NIHSS score and ADL score （P0 .05） .Conclusion Edaravone could improve the clinical treatment effect of acute ischemic cerebrovascular disease ,and reducing se‐rum CRP and MMP‐9 level mechanism pathway might be involved in the regulation of its pharmacodynamics .
出处
《重庆医学》
CAS
北大核心
2015年第3期334-336,共3页
Chongqing medicine
关键词
急性病
脑缺血
神经系统疾病
依达拉奉
临床效果
acute disease brain ischemia nervous system disease edaravone clinical effect
