摘要
目的探讨低分子肝素在增生性糖尿病视网膜病变行玻璃体切除手术过程中的作用。方法139例（147只眼）增生性糖尿病视网膜病变随机分为A、B两组。A组为玻璃体切除术术中应用低分子肝素组，86例（90只眼）；B组为术中未应用低分子肝素组，53例（57只眼）。比较两组术中医源性裂孔的发生率、术后玻璃体再积血及治疗稳定后的视力情况。结果发生医源性裂孔者A组7只眼（7．78％），B组12眼（21．05％），两组差异有统计学意义（χ^2=5．46，P=0．01）。术后发生玻璃体再出血者A组13只眼（14．44％），B组9只眼（15．79％），两组差异无统计学意义（χ^2=0．05，P=0．82）。治疗稳定后视力0．3及以上者，A组51只眼（56．67％），B组17只眼（29．82％），两组差异有统计学意义（χ^2=10．11，P=0．00）。结论增生性糖尿病视网膜病变玻璃体切除术术中应用低分子肝素，能减少医源性裂孔的发生，并可获得较好的视力。
Objective To investigate the effect of low molecular weight heparin in vitrectomy for proliferative diabetic retinopathy （PDR）. Methods One hundred and forty-seven eyes of 139 PDR patients were divided into two groups randomly. Group A, in which the low molecular weight heparin was used during the surgery, 90 eyes of 86 patients; and Group B, the non-application group, 57 eyes of 53 patients. The i- atrogenic retinal tear, postoperative vitreous hemorrhage and the final visual acuity were compared between two groups. Results Iatrogenic retinal tear occurred in 7 eyes （ 7. 78% ） in group A while 12 eyes （21.05%） in group B and the difference was statistically significant（χ^2 =5.46, P =0.01 ）. Vitreous hem- orrhage occurred in 13 eyes（ 14.44% ） in group A while 9 eyes（ 15.79% ） in group B and the difference was not statistically significant（χ^2 =0. 05, P =0.82）. The final visual acuity was better than 0.3 in 51 eyes （56.67%） in group A and in 17 eyes（29.82% ） in group B. The difference was statistically significant be- tween two groups （χ^2 = 10. 11, P = 0.00 ）. Conclusion The application of low molecular weight heparin during PDR surgery can reduce the iatrogenic retinal tear incidence and bring the better vision for the pa- tients.
出处
《中华眼外伤职业眼病杂志》
2015年第1期15-17,共3页
Chinese Journal of Ocular Trauma and Occupational Eye Disease
关键词
肝素
低分子
视网膜病变
糖尿病
增生性
裂孔
医源性
Heparin, low molecular weight
Retinopathy, diabetic, proliferative
Tear, retinal, iatrogenic
