摘要
目的:了解朝阳地区孕妇的TORCH感染情况,及随访TORCH-Ig M抗体阳性孕妇的不良妊娠结局,为提高孕妇保健工作提供实验数据。方法:对就诊的2365例孕妇采集血清,采用捕获法ELISA原理检测TORCH-Ig M抗体,用ELISA间接法原理检测TORCH-Ig G抗体。结果:2365例早孕妇进行TORCH特异性抗体Ig M和Ig G检测,筛查出5种病原体特异性Ig M抗体阳性孕妇共25例,总阳性率为1.05%。从感染的情况看,CMV(0.34%)>HSV(0.25%)>RV(0.25%)>TOX(0.16%),CMV感染率最高,其次为HSV、RV。CMV、HSVⅠ、RV特异性抗体Ig G在妊娠状态下均有较高的检出率,分别为:89.85%、89.89%、81.48%。25例TORCH感染孕妇中不良妊娠结局14例,流产发生率最高为47.26%(10/21),另外11例在孕期均抽取羊水细胞培养,诊断出3例异常核型。结论:对育龄妇女进行TORCH(Ig M、Ig G)孕前筛查可有效的减少异常患儿的出生,TORCH检测在孕期筛查中有重要意义。
Objective： To investigate the infection of pregnant women in Chaoyang area TORCH, and followup of TORCH-IgM antibody positive pregnant women with adverse pregnancy outcomes, in order to improve the health care of pregnant women and provide experimental data.Method： 2365 cases of pregnant women serum on treatment of acquisition, detection of TORCH-IgM antibody by capture ELISA method for TORCH-IgG antibody detection principle, the principle of indirect ELISA method. Result： 2365 cases of early pregnant women were TORCH specific antibody detection of IgM and IgG positive pregnant women, screening of specific IgM antibody of five kinds of pathogens in 25 cases, the total positive rate was 1.05%. From the infection situation, CMV （ 0.34% ）, HSV （ 0.25% ） 〉RV （ 0.25% ） 〉TOX （ 0.16% ）, CMV infection rate was the highest, followed by HSV, RV. CMV, HSV I, RV specific antibody IgG in pregnancy condition had a higher detection rate, respectively： 89.85%, 89.89%, 81.48%. In 14 cases of pregnant women with adverse pregnancy outcome of 25 cases of TORCH infection, the highest incidence of abortion. The other 11 cases were sampled during pregnancy amniotic fluid cell culture, diagnosed 3 cases of abnormal karyotype. Conclusion： TORCH is performed in women of childbearing age （ IgM, lgG ） screening before pregnancy can effectively reduce the abnormal infants birth, TORCH detection is of important significance in prenatal screening.
出处
《中国医学创新》
CAS
2015年第3期69-71,共3页
Medical Innovation of China
基金
辽宁省博士启动基金(20141134)
