摘要
目的探讨高胆红素血症新生儿听力损失程度与血清胆红素水平的相关性。方法对70例足月出生、体重正常、确诊为高胆红素血症的新生儿进行血清胆红素水平及听性脑干反应(ABR)检测,并对其血清胆红素水平、黄疸出现时间与ABR反应阈进行相关性分析。结果 70例患儿中ABR反应阈正常17例,异常53例,其中重度听力损失27例;当血清胆红素<342μmol/L时,黄疸出现时间≤48小时组出现重度听力损失的比例高于黄疸出现时间>48小时组(P<0.05),而血清胆红素值≥342μmol/L时,黄疸出现时间≤48小时组与>48小时组轻中度、重度听力损失者比例无明显差异。ABR反应阈异常的53例患儿中,血清胆红素水平与ABR反应阈呈正相关(r=0.041),而黄疸出现的时间与ABR反应阈呈负相关(r=-0.291)。结论高胆红素血症新生儿黄疸出现的时间越早听力损伤的可能性越大,血清胆红素值越高听力损失程度越重。
Objective To study the relationship between hearing loss and serum bilirubin of neonates with hypercholesterolemia .Methods The serum bilirubin level and auditory brainstem response thresholds of 70 hyper_cholesterolemia neonates of full term pregnancy and normal weight were tested ,and the correlations of serum biliru_bin ,and occurrence time of jaundice with hearing threshold were analyzed .ResuIts Among the 70 neonates ,there were 17 cases with normal ABR thresholds and 53 with abnormal ABR thresholds ,including 27 with middle and se_rious hearing loss .In the cases of serum bilirubin less than 342μmol/L ,the percentage of cases with middle and se_rious hearing loss and with occurrence time of jaundice less than 48 hours was higher than theses cases with occur_rence time of jaundice more than 48 hours （P〈0 .05） .In the cases of serum bilirubin higher than 342μmol/L ,there was no obvious difference between the percentage of cases of middle and serious hearing loss with occurrence time of jaundice less than 48 hours and those with occurrence time of jaundice more than 48 hours .Among the 53 cases with abnormal hearing thresholds ,positive correlation was observed between serum bilirubin and ABR threshold （r=0 .041） ,whereas negative correlation was observed between occurrence time of jaundice and ABR threshold （r=-0 .291） .ConcIusion The higher probability of hearing loss for hypercholesterolemia neonates with earlier occur_rence of jaundice ,the more serious hearing loss with higher serum bilirubin .
出处
《听力学及言语疾病杂志》
CAS
CSCD
北大核心
2015年第1期37-39,共3页
Journal of Audiology and Speech Pathology
关键词
足月新生儿
黄疸
血清胆红素
听力损失
Full term pregnancy neonate
Jaundice
Serum bilirubin
Hearing loss
