摘要
肥胖个体多伴有慢性低度炎症状态，体内正常的平衡状态被破坏，并出现氧化应激，内质网应激是心血管疾病和诸多慢性代谢病的高危因素。血红素加氧酶-1（Heine oxygene-1，HO-1）是一种组织保护酶，具有明显的抗氧化和抗炎作用，能够显著改善肥胖个体脂肪细胞功能，增强胰岛素的敏感性等。针对HO．1在肥胖个体内的抗炎作用以及干预措施的研究，在改善肥胖炎症状态及其引起的相关疾病方面具有十分重要的意义。该文对肥胖个体脂肪中HO-1的变化以及对炎症反应中巨噬细胞浸润的影响进行阐述。
Obesity is mostly recognized as a chronic inflammatory condition in which the balance of normal state is destroyed and it is a risk of cardiovascular disease and many other chronic metabolic disease. Heme oxygenase-1 （HO-I）, a major cytoprotective enzyme,exerts significant antioxidant and anti-inflammatory effects. It also can improve the function of fat cells and enhanced insulin sensitivity in obese individuals. The researches of HO-1 for the anti-inflammatory effects and its intervention have great significance in improving the inflammatory state and its related diseases in obesity. This paper elaborates the change of HO-1 and its effect for macrophage infiltration in obesity.
出处
《国际儿科学杂志》
2015年第1期21-24,共4页
International Journal of Pediatrics
