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感染炎性因子对成体动物海马区神经元再生的影响 被引量：2

Effects of inflammatory cytokines on adult hippocampal neurogenesis
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摘要 在中枢神经系统,外部感染等引起的炎症反应中起重要作用的是由活化的胶质细胞产生的炎性因子,包括促炎因子(如白细胞介素1,6、肿瘤坏死因子-α、干扰素、趋化因子等)和抗炎因子(如白细胞介素4,10、转化生长因子β等)。海马作为学习和记忆相关的重要结构,其神经元再生受损可能与年老所致认知功能下降以及阿尔兹海默病、抑郁等疾病有关。而中枢神经系统炎症作为大脑损伤及许多神经退行性病变的并发症,对神经元再生的影响已引起了广泛的关注。炎性因子的种类、释放的时间及含量不同,可对神经元再生产生不同的影响。 In the central nervous system, infections and trauma may result in inflammation. The inflammatory cytokines produced by activated glial cells include pro-inflammatory cytokines （e. g. , interleukin-1 ＆ 6, tumor necrosis factor-α, interferon, chemokines, etc. ） and anti-inflammatory cytokines （e. g. , interleukin-4 ＆ 10, transforming growth factor β, etc. ）. Adult neurogenesis is subject to the modulation by various physiological and pathological stimuli. Hippocampus is important for some forms of learning and memory functions, and the defects of hippoeampal neurogenesis could be associated with aging related cognitive decline, Alzheimer＇s disease, depression and other diseases. However, as the complications of brain trauma and neurodegeneration, central nervous system inflammation has attracted wide attentions. With special types, releasing time and content, inflammatory eytokines play different roles in neurogenesis.
作者 雷腾腾 孙文长 范晓磊
机构地区 大连医科大学微生物学教研室
出处 《中国微生态学杂志》 CAS CSCD 2014年第12期1468-1470,共3页 Chinese Journal of Microecology
基金 大连市科技计划项目(2011E12SF033)
关键词 炎性因子 成体神经元再生 海马 Inflammation cytokines Adult neurogenesis Hippocampus
分类号 R392.11 [医药卫生—免疫学]
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参考文献22

  • 1Ming GL, Song H. Adult neurogenesis in the mammalian brain : sig- nificant answers and significant questions [ J ]. Neuron, 2011, 70 (4) : 687-702.
  • 2Zhao C, Deng W, Gage FH. Mechanisms and functional implica- tions of adult neurogenesis[J]. Cell, 2008, 132(4) : 645-660.
  • 3Alvarez-Buylla A, Lira DA. For the long run: maintaining germinal niches in the adult brain[J]. Neuron, 2004, 41 (5) : 683-686.
  • 4Monje ML, Toda H, Palmer TD. Inflammatory blockade restores a- dult hippoeampal neurogenesis [ J ]. Science, 2003, 302 (5651) : 1760-1765.
  • 5Fujioka H, Akema T. Lipopolysaecharide acutely inhibits prolifera- tion of neural precursor cells in the dentate gyms in adult rats[ J]Brain Res, 2010, 1352(1) : 35-42.
  • 6Cacti E, Ajmone-Cat MA, Anelli T, et al. In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of mieroglia [J], Glia, 2008, 56(4): 412-425.
  • 7Wu MD, Hein AM, Moravan MJ, et al. Adult murine hippocampal neurogenesis is inhibited by sustained IL-1 and not rescued by vol- untary running[J]. Brain Behav Immun, 2012, 26(2) : 292-300.
  • 8Ryan SM, O'Keeffe GW, O'Connor C, et al. Negative regulation of TLX by IL-113 correlates with an inhibition of adult hippocampal neural precur-mr cell proliferation[J]. Brain Behav Immun, 2013, 33(1): 7-13.
  • 9Mathieu P, Battista D, Depino A, et al. The more you have, the less you get : the functional role of inflammation on neuronal differ- entiation of endogenous and transplanted neural stem cells in the a- dult brain[J]. J Neurochem, 2010, 112(6) : 1368-1385.
  • 10Goshen I, Kreisel T, Ounallah-Saad H, et al. A dual role for in- terleukin-1 in hippocampal-dependent memory processes[ J]. Psy- choneuroendocrinol, 2007, 32(8-10): 1106-1115.

二级参考文献48

  • 1韩杰,李明,郑莉莎.阿尔茨海默病患者血清与脑脊液中多种细胞因子的研究[J].中华老年心脑血管病杂志,2005,7(2):112-114. 被引量：6
  • 2肖党生,王招娣,杨云梅,陈春雷,洪鸣鸣.糖尿病患者肠道菌群研究[J].中国微生态学杂志,2006,18(4):275-276. 被引量：33
  • 3康白.微生态学原理[M].大连:大连出版社,2002.180.
  • 4HOSOKAWA T, KIKUCHI Y, NIKOH N, et al. Strict host-symbiont co- speciation and reductive genome evolution in insect gut bacteria [ J ]. PLoS Biol,2006,4(10) :e337.
  • 5RAVEL J, ,PAWEL GAJER,ZAID ABDO,et al. Vaginal microbiome of reproductive-age women [ J ]. Proc Natl Acad Sci U S A, 2011,108 ( suppl 1 ) :4680-687.
  • 6TORRAZZA M R, NEU J. The developing intestinal microbiome and its relationship to health and disease in the neonate [ J ]. J Perinatol,2011 , 31 ( suppl 1 ) : S29-S34.
  • 7JIMtNEZ E, MARIN M L, MARTIN R,et al. Is meconium from healthy newborns actually sterile? [ J J. Res Microbiol, 2008,159 (3) : 187- 193.
  • 8MITSOU E K, KIRTZALIDOU E, OIKONOMOU I, et al. Fecal micro- flora of Greek healthy neonates[ J]. 2008,14(2) :94-101.
  • 9SAMUEL B S, ABDULLAH SHAITO,TOSHIYUKI MOTOIKE, et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptorGpr41 [ J ]. Proc Natl Acad Sci U S A,2008,105(43) :16767-16772 .
  • 10AGANS R, RIGSBEE L, KENCHE H, et ah Distal gut microbiota of ad- olescent children is different fi'om that of adults [ J ]. FEMS Microbiol Ecol,2011,77(2) :404412.

共引文献15

同被引文献21

  • 1Willing BP, Russell SL, Finlay BB. Shifting the balance: antibiotic effects on host-microbiota mutualism [ J]. Nat Rev Microbiol, 2011, 9(4) : 233-243.
  • 2Collins SM, Bercik P. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease [ J ]. Gastroenterology, 2009, 136 ( 6 ) : 2003-2014.
  • 3Fraune S, Bosch TC. Why bacteria matter in animal development and evolution[J].Bioessays, 2010, 32(7): 571-580.
  • 4Wang Y, Kasper LH. The role of microbiome in central nervous sys- tem disorders[J]. Brain Behav Immun, 2014, 38: 1-12.
  • 5Bercik P, Denou E, Collins J, et al. The intestinal microbiota af- fect central levels of brain-derived neurotropic factor and behavior in miee[J:. Gastroenterology, 2011, 141(2): 599-609.
  • 6Rhee SH, Pothoulakis C, Mayer EA. Principles and clinical impli- cations of the brain-gut-enteric microbiota axis[ J]. Nat Rev Gastro- enterol Hepatol, 2009, 6(5) : 306-314.
  • 7Ochoa-Repdraz J, Mielcarz DW, Wan Y, et al. A polysaccharide from the human commensal Bacteroide sfragile protects against CNS demyelinating disease[ J]. Mucosal Immunol, 2010, 3 ( 5 ) : 487- 495.
  • 8Moyagally MA, Neshat S, Lomax AE. Inhibition of sympathetic N- type voltage-gated Ca2 : current underlies the reduction in norepi- nephrine release during colitis [ J ]. Am J Physiol Gastrointest Liver Physiol, 2009, 296(5): G1077-G1084.
  • 9Jacobson K, Mchugh K, Collins SM. The mechanism of altered neural function in a rat model of acute colitis [ J ]. Gastroenterology, 1997, 112(1): 156-162.
  • 10Magro F, Vieira-Coelho MA, Fraga S, et al. Impaired synthesis or cellular storage of norepinephrine, dopamine, and 5- hydroxytryptamine in human inflammatory bowel disease [ J ]. Dig Dis Sci, 2002, 47(1): 216-224.

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中国微生态学杂志
2014年 第12期

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