摘要
采用正相硅胶色谱柱、Sephadex LH-20以及制备HPLC等色谱方法对羊耳菊进行分离纯化,并通过理化常数和波谱数据鉴定其化学结构。深入研究羊耳菊干燥全草的咖啡酰基奎宁酸类化学成分。从羊耳菊中分离得到8个咖啡酰基奎宁酸类化合物,分别为1,5-O-二咖啡酰基奎宁酸（1）、1,3,5-O-三咖啡酰基奎宁酸（2）、3,5-O-二咖啡酰基奎宁酸甲酯（3）、3,4-O-二咖啡酰基奎宁酸甲酯（4）、3,4-O-二咖啡酰基奎宁酸乙酯（5）、4,5-O-二咖啡酰基奎宁酸乙酯（6）、3,5-O-二咖啡酰基奎宁酸（7）、3,4-O-二咖啡酰基奎宁酸（8）。化合物1-3为从该植物中首次分离得到,4-6从该属植物中首次分离得到。
The caffeoylquinic acid derivatives from the whole plant of Inula cappa were isolated by using a combination of various chromatographic techniques including silica gel chromatography,Sephadex LH-20 chromatography and preparative HPLC. Their structures were identified by their physical-chemical properties and spectroscopic analysis. Eight compounds were isolated and identified as 1,5-di-O-caffeoylquinic acid（ 1）,1,3,5-tri-O- caffeoylquinic acid（ 2）,methyl 3,5-di-O-caffeoyl- quinate（ 3）,methyl 3,4-di-O-caffeoylquinate（ 4）,ethyl 3,4-di-O-caffeoylquinate（ 5）,ethyl 4,5-di- Ocaffcoylquinate（ 6）,3,5-di-O-caffeoylquinic acid（ 7）,3,4-di-O-caffeoylquinic acid（ 8）. Compounds 1-3 were isolated from this species for the first time. Compounds 4-6 were found from the genus firstly.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2014年第12期1948-1952,共5页
Natural Product Research and Development
基金
国家自然科学基金(81360680)
国家科技支撑计划课题(2013BAI11B01)
贵州省中药现代化科技产业研究开发专项(2013-4001)
关键词
羊耳菊
化学成分
咖啡酰基奎宁酸
Inula cappa
chemical constituent
caffeoylquinic acid derivative
