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影响高龄男性血清甲状旁腺素的独立相关因素 被引量：13

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摘要 随着我国人口老龄化程度的加重,高龄（≥80岁）男性越来越多。临床常发现高龄男性血清甲状旁腺素（parathyroid hormone,PTH）增高,但经B超和CT等检查未发现有功能亢进的甲状旁腺病灶。人体内源性PTH在甲状旁腺主细胞内质网中合成,是84个氨基酸残基组成的多肽,是体内调节血钙磷水平的主要激素之一,其持续升高可促进骨吸收,导致骨质疏松。
作者 边平达 应奇峰 李秀央 陈锦平
机构地区 浙江省人民医院望江山院区骨质疏松诊疗中心 浙江大学流行病与卫生统计学系
出处 《中华骨质疏松和骨矿盐疾病杂志》 2014年第4期340-343,共4页 Chinese Journal Of Osteoporosis And Bone Mineral Research
关键词 甲状旁腺素 甲状旁腺主细胞 甲状旁腺病灶 骨质疏松 PARATHYROID 体内调节 骨代谢指标 血磷 骨吸收 骨钙素
分类号 R582 [医药卫生—内分泌]
  • 相关文献

参考文献14

  • 1Kim G, Oh KW, Jang EH, et al. Relationship between vitamin D, parathyroid hormone, and bone mineral density in elderly Koreans [ J]. J Korean Med Sci, 2012, 27: 636-643.
  • 2王春艳,李梅,邢小平.原发性骨质疏松症中影响甲状旁腺素水平的因素分析[J].中华骨质疏松和骨矿盐疾病杂志,2010,3(1):64-68. 被引量：4
  • 3Houghton LA, Gray AR, Szymlek-Gay EA, et al. Vita- min D-fortified milk achieves the targeted serum 25- hydroxyvitamin D concentration without affecting that of parathyroid hormone in New Zealand toddlers [ J ]. J Nutr, 2011, 141: 1840-1846.
  • 4Sahota O, Mundey MK, San P, et al. The relationship between vitamin D and parathyroid hormone: calcium ho- meostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis [ J 1. Bone, 2004, 35: 312-319.
  • 5Salinas M, Lopez-Garrigos M, Pomares F, et al. Serum calcium (S-Ca) , the forgotten test: preliminary results of an appropriateness strategy to detect primary hyperparathy- roidism (pHPT) [ J]. Bone, 2013, 56: 73-76.
  • 6Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses [ Jl. J Appl Physiol, 2011, 111: 537-542.
  • 7Civitelli R, Ziambaras K. Calcium and phosphate homeo- stasis : concerted interplay of new regulators [ J ]. J Endo- crinol Invest, 2011, 34: 3-7.
  • 8边平达,应奇峰,李秀央,陈锦平.80岁以上高龄老人骨密度与骨转换标志物的相关性研究[J].中华内分泌代谢杂志,2014,30(3):206-209. 被引量：31
  • 9Rianon N, Alex G, Callender G, et al. Preoperative ser- um osteocalcin may predict postoperative elevated parathy- roid hormone in patients with primary hyperparathyroidism [ J~. World J Surg, 2012, 36: 1320-1326.
  • 10Schafer AL, Sellmeyer DE, Schwartz AV, et al. Change in under carboxylated osteocalcin is associated with chan- ges in body weight, fat mass, and adiponectin: parathy- roid hormone (1-84) or alendronate therapy in postmeno- pausal women with osteoporosis (the PaTH study) [ J l. J Clin Endocrinol Metab, 2011, 96: E1982-1989.

二级参考文献33

  • 1Sergio Rueda,Cristian Fernández-Fernández,Fabiola Romero,Ma. Jesús Martínez de Osaba,Josep Vidal.Vitamin D, PTH, and the Metabolic Syndrome in Severely Obese Subjects[J]. Obesity Surgery . 2008 (2)
  • 2S. Patel,S. Hyer,J. Barron.Glomerular Filtration Rate Is a Major Determinant of the Relationship between 25-Hydroxyvitamin D and Parathyroid Hormone[J]. Calcified Tissue International . 2007 (4)
  • 3R. K. Rude,H. E. Gruber,H. J. Norton,L. Y. Wei,A. Frausto,J. Kilburn.Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism[J]. Osteoporosis International . 2006 (7)
  • 4O. Sahota,M. K. Mundey,P. San,I. M. Godber,D. J. Hosking.Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency[J]. Osteoporosis International . 2006 (7)
  • 5A. G. Need,A. Kemp,N. Giles,H. A. Morris,M. Horowitz,B. E. C. Nordin.Relationships Between Intestinal Calcium Absorption, Serum Vitamin D Metabolites and Smoking in Postmenopausal Women[J]. Osteoporosis International . 2002 (1)
  • 6M.-C. Chapuy,P. Preziosi,M. Maamer,S. Arnaud,P. Galan,S. Hercberg,P.J. Meunier.Prevalence of Vitamin D Insufficiency in an Adult Normal Population[J]. Osteoporosis International . 1997 (5)
  • 7Johannesson JP,Indridason OS,Franzson L,et al.Assessment of age-related changes in parathyroid hormone levels by different methods. Laeknabladid . 2003
  • 8Gunnarsson O,Indridason OS,Franzson L,et al.Factors associated with elevated or blunted PTH response in vitamin D insufficient adults. Journal of Internal Medicine . 2008
  • 9Neuprez A,Bruyere O,Collette J,et al.Vitamin D inadequacy in Belgian postmenopausal osteoporotic women. Journal of Clinical Endocrinology and Metabolism . 2007
  • 10Rude RK,Gruber HE.Magnesium deficiency and osteoporosis: animal and human observation. J Nutr Bioch . 2004

共引文献37

同被引文献67

引证文献13

二级引证文献43

中华骨质疏松和骨矿盐疾病杂志
2014年 第4期

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