摘要
目的:观察中西药联合疗法对糖尿病周围神经病变(DPN)的治疗作用及安全性。方法:选取本院确诊为DPN患者120例,随机分为治疗组与对照组,两组均给予常规降糖治疗,治疗组在常规治疗的基础上加用甲钴胺500μg皮下注射+糖痹宁口服治疗,对照在常规治疗的基础上仅给予甲钴胺500μg皮下注射治疗,两组均治疗8周,对比治疗前后两组正中神经、腓总神经运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)改善情况,并观察治疗前后两组中医症候评分改善情况及临床疗效。结果:两组治疗后正中神经、腓总神经MNCV、SNCV均较治疗前改善,治疗组改善较对照组更为明显,差异具有统计学意义(P<0.05);两组治疗后中医症候评分均较治疗前改善,治疗组治疗后中医症候评分改善程度较对照组更为明显,差异具有统计学意义(P<0.05);治疗组治疗后总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论:甲钴胺联合糖痹宁可有效缓解DPN临床症状,疗效明显,且无明显不良反应,是治疗DPN的有效方案。
Objective： To observe the therapeutic effect of the combination of the traditional Chinese and western medi- cine in treating diabetic peripheral neuropathy （DPN） and its safety. Methods： A total of 120 patients diagnosed as DPN in our hospital were enrolled in the study and randomized in the treatment group and the control group. The patients in the two groups were given conventional blood glucose reducing treatment. Based on the conventional treatment, subcutaneous injection of 500 ug methyl cobalamin and oral administration of Tang bining were added to the treatment group, the control group only received subcutaneous injection of 500 ug methyl cobalamin on the basis of conventional treatment. The patients in the two groups were treated for eight weeks. The improvements o~ median nerve and nervus peroneus communis conduction velocity （MNCV） and sensory nerve conduction velocity （SNCV） in the two groups before and after treatment were compared, and the improvement of syndrome of Chinese medicine scores in the two groups before and after treatment and the clinical efficacy were observed. Results： After treatment, the MNCV and SNCV in the two groups were significantly improved when compared with those before treatment （P〈0.05）, the improvement in the treatment group was more obvious than that in the control group（P〈0.05）. The syndrome of Chinese medicine scores in the two groups after treatment was significantly improved when com- pared with that before treatment （P〈0.05）, the improvement in the treatment group was more obvious than that in the con- trol group （P〈0.05）. The total effective rate in the treatment group after treatment was significantly higher than that in the control group and there was a statistically significant difference between the two groups （P〈0.05）. Conclusions：Methyl co- balamin in combined with Tang bining can effectively alleviate the DPN clinical symptoms with a significant effect and no obvi- ous adverse reactions are observed; therefore, it is an effective method to treat DPN.
出处
《海南医学院学报》
CAS
2014年第12期1660-1662,共3页
Journal of Hainan Medical University
基金
宣钢集团科技进步项目(2013045302)~~
关键词
甲钴胺
糖痹宁
糖尿病周围神经病变
Methyl cobalamin, Tang bining, Diabetic peripheral neuropathy
