摘要
目的:研究保留肾单位手术与根治性肾切除术对T1b期肾癌患者血清炎症因子、肿瘤恶性生物学行为的影响。方法:将本院收治的120例T1b期肾癌患者纳入研究,随机分为两组,观察组接受保留肾单位手术,对照组接受根治性肾癌切除术,随访两组远期复发情况,采集外周血检测炎症因子、血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP)含量。结果:术后1、2、3年时,两组复发率无差异;观察组的血清白细胞介素-1(IL-1)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、VEGFA、VEGFB、VEGFC、MMP-2、MMP-9含量均低于对照组。结论:保留肾单位手术有助于缓解炎症反应、控制肿瘤恶性生物学行为,并且不会增加远期复发率,是治疗T1b期肾癌的理想方法。
Objective： To study the effects of nephron sparing operation and radical nephrectomy on inflammatory fac tors and malignant tumor biological behavior of stage Tlb renal cell carcinoma. Methods： 120 cases of stage Tlb renal cell car- cinoma patients in our hospital were randomly divided into two groups. Observation group received nephron sparing operation and control group received radical nephrectomy. Then long term recurrence were followed, serum inflammatory factors, VEGF, MMP content were detected. Results： 1 years, 2 years, 3 years after surgery, recurrence rate of two groups was not significantly differents serum IL- 1, CRP, TNF-α, VEGFA, VEGFB, VEGFC, MMP2, MMP9 content of observation group were lower than those of control group. Conclusions： Nephron sparing operation is helpful to relieve inflammation reaction, control the malignant biological behavior of tumor and dose not increase long-term recurrence rates it＇s an ideal method in trea- ting T1b stage renal ceil carcinoma.
出处
《海南医学院学报》
CAS
2014年第12期1724-1726,共3页
Journal of Hainan Medical University
基金
湖北省科技厅科学技术项目(2005AA301C32)~~
关键词
肾癌
保留肾单位手术
炎症因子
血管内皮生长因子
基质金属蛋白酶
Renal cell carcinoma
Nephron sparing operation
Inflammatory factors Vascular endothelial growth factor
Matrix metalloproteinase
