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多重耐药铜绿假单胞菌临床分布及耐药性分析 被引量：6

Analysis on clinical distribution and drug resistance of multidrug-resistant Pseudomonas aeruginosa
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摘要 目的：了解多重耐药（MDR）铜绿假单胞菌临床分布及耐药情况，为合理使用抗菌药物提供依据。方法菌株来自2009年1月至2013年12月该院住院患者的痰液、尿液、伤口分泌物等各种送检标本进行细菌学培养。结果2009年1月至2013年12月共分离铜绿假单胞菌200株，其中 MDR 菌株51株，占25.5％。分离出的 MDR 菌株分布在呼吸内科病房（80.4％）、外科病房（17.9％）。痰标本分离的 MDR 菌株占64.7％，其次为伤口分泌物占19.6％，尿液占11.8％。铜绿假单胞菌对氨苄西林／舒巴坦耐药情况严重，耐药率为100.0％；对阿米卡星、亚胺培南、美罗培南、哌拉西林／他唑巴坦、环丙沙星、左氧氟沙星和多黏菌素 E 耐药率较低，依次为28.9％、29.4％、25.0％、30.4％、34.5％、34.5％和8.3％；对其余常用抗菌药物的耐药率为39.0％～58.3％。铜绿假单胞菌泛耐药菌14株，检出率为7.0％。结论多重耐药铜绿假单胞菌耐药性更加严重，各种细菌之间耐药性差异较大，临床应根据药敏结果使用抗菌药物。 Objective To investigate the clinical distribution and drug resistance of multidrug-resistant （MDR）Pseudomonas aeruginosa to provide reference for clinical rational use of antibacterial drugs.Methods The strains were originated from bacterial culture in the samples of sputum,urine and wound secretion collected from the inpatients admitted in our hospital from January 2009 to December 2013.Results 200 strains of Pseudomonas aeruginosa were isolated during this period,in which 51 strains were MDR,accounting for 25.5%.The isolated MDR Pseudomonas aeruginosa strains were mainly distributed in the the respiratory de-partment（80.4%）and the surgical department（17.9%）.MDR strains isolated from the sputum specimens accounted for 64.7%, followed by the wound secretion（19.6%）and urine（11.8%）.Pseudomonas aeruginosa was seriously resistant to ampicillin-sulbac-tam with the resistance rate of was 100.0%,but had the low resistance rate to amikacin,imipenem,meropenem,piperacillin/tazobactam,ciprofloxacin,levofloxacin,polymyxin E,which were 28.9%,29.4%,25.0%,30.4%,34.5%,34.5% and 8.3%;the resistance rate to commonly used antibacterial drugs was 39.0%-58.3%.14 strains were pan-drug resistant Pseudomonas aerugi-nosa（PDR-PA）;The detection rate was 7.0%.Conclusion The drug resistance of MDR Pseudomonas aeruginosa is more serious, the clinical application of anibiotics should be perfromed based on the result of drug susceptibility test.
作者 吴朝阳 黄婷 谭穗茹
机构地区 中山市民众医院 中山市开发区医院检验科
出处 《国际检验医学杂志》 CAS 2014年第23期3222-3223,共2页 International Journal of Laboratory Medicine
关键词 多重耐药 铜绿假单胞菌 耐药性 泛耐药 临床分布 multidrug resistance pseudomonas aeruginosa drug resistance pandrug-resistance clinical distribution
分类号 R446.5 [医药卫生—诊断学]
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参考文献9

二级参考文献51

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共引文献904

同被引文献53

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引证文献6

二级引证文献21

国际检验医学杂志
2014年 第23期

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