摘要
目的研究医院获得性患者铜绿假单胞菌分布特点以及药敏试验情况,为临床治疗提供参考。方法对484例医院获得性痰标本进行细菌培养鉴定及药敏试验,研究铜绿假单胞菌的感染情况及药敏特点。结果 484例医院获得性肺炎革兰阴性杆菌检出389株,占80.37%,以铜绿假单胞菌为主,检出207株,占42.77%,革兰阳性球菌95株,占19.63%,革兰阴性杆菌与革兰阳性球菌构成比差异有统计学意义(χ2=354.38,P=0.000,P<0.05)。铜绿假单胞菌感染呈现增长态势;年龄分布51岁以上老人居多,占42.51%;药敏试验头孢呋辛、环丙沙星、左氧氟沙星及替卡西林/克拉维酸耐药率较高,分别达96.6%、65.3%和49.3%、49.3%,亚胺培南未发现耐药菌株。结论铜绿假单胞菌为引起医院获得性感染的重要菌群,多重耐药常见,临床治疗过程中应根据药敏试验合理使用抗菌药物。
Objective To study the distribution characteristics and the drug susceptibility testing in the patients with hospital-acquired Pseudomonas aeruginosa（PA）infection to provide reference for clinical treatment.Methods The sputum specimens from 484 cases of hospital-acquired infection were performed the bacterial culture identification and the drug susceptibility testing for studying the Pseudomonas aeruginosa infection situation and the drug sensitivity characteristics.Results Among 484 cases of hos-pital-acquired pneumonia,389 strains of Gram-negative bacilli were detected out,accounting for 80.37%,Pseudomonas aeruginosa was predominant,207 strains were detected out,accounting for 42.77%;95 strains were Gram-positive cocci,accounting for 19.63%.the constituent ratio of Gram-negative bacilli and Gram-positive cocci had the statistical difference （χ2 = 354.38,P =0.000,P 〈0.05）.The Pseudomonas aeruginosa infection revealed the increasing trend;in the age distribution,the majority were the elderly aged more than 51 years old,accounting for 42.51%;the drug susceptibility testing showed that cefuroxime,ciprofloxacin, levofloxacin and ticarcillin/clavulanic acid had the higher resistance rates,which reached 96.6%,65.3%,49.3% and 49.3% re-spectively,imipenem-resistant strains was not found.Conclusion Pseudomonas aeruginosa is an important bacterium of hospital-ac-quired bacterial infections,multi-drug resistance is common,the antimicrobial drugs should be rationally used during clinical treat-ment course according to the drug susceptibility testing.
出处
《国际检验医学杂志》
CAS
2014年第23期3230-3231,3238,共3页
International Journal of Laboratory Medicine
关键词
医院获得性肺炎
铜绿假单胞菌
药物敏感试验
hospital-acquired pneumonia Pseudomonas aeruginosa drug susceptibility testing
