摘要
目的以体外释放度和经皮渗透性为指标,制备醋氯芬酸贴剂并优化压敏胶和促渗剂的处方。方法采用不同类型丙烯酸酯压敏胶为基质制备醋氯芬酸贴剂,以体外释放度为指标考察筛选压敏胶;以不同种类促渗剂制备醋氯芬酸贴剂,采用改良Franz扩散池,以离体大鼠皮肤为渗透屏障,考察其经皮渗透性能,筛选经皮渗透促进剂。结果醋氯芬酸贴剂在12 h内体外释放曲线遵循Higuchi动力学方程,经皮渗透曲线遵循零级动力学方程,且以Duro Tak 87-2677为压敏胶基质、质量分数为5%的氮酮为促渗剂时醋氯芬酸贴剂具有较快的释放和经皮渗透速率。结论醋氯芬酸贴剂为皮肤控释型骨架释药系统,选择适宜的基质和促渗剂可保证足够的药物释放并穿透皮肤发挥理想的治疗作用。
Objective To investigate the preparation of aceclofenac transdermal patches（ATPs）.Methods The releasing test and the penetration test of ATPs were determined by HPLC for the screening of the best acrylic copolymer pressure-sensitive adhesives and the best penetration enhancers.Results The cumulative releasing curves and the cumulative percutaneous penetration curves were respectively fitted to Higuchi kinetic equation and zero-order equation.The best formulation was aceclofenac/Duro Tak 87-2677 with 5%（w） of azone.Conclusion Aceclofenac transdermal patches,which possess good releasing and penetration behavior,have high developing value.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2014年第12期940-943,共4页
Journal of Shenyang Pharmaceutical University
关键词
醋氯芬酸贴剂
丙烯酸酯压敏胶
释放度
促渗剂
经皮渗透
aceclofenac transdermal patches
acrylic copolymer pressure-sensitive adhesives
release
enhancer
transdermal penetration
