炎症及氧化应激反应在慢性阻塞性肺疾病发病机制中的研究进展被引量：41

Research Progress on the Pathogenesis of Chronic Obstructive Pulmonary Disease

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摘要慢性阻塞性肺疾病是一种复杂的全身性疾病,发病机制尚未完全清楚.气道和肺部炎症、氧化/抗氧化失衡和蛋白酶/抗蛋白酶失衡被认为是3个主要的发病机制.就细胞因子和炎症介质、氧化应激反应和蛋白酶/抗蛋白酶系统在COPD发病中所起的作用等方面的研究进展作一综述. Chronic obstructiue pulmonary disease （COPD） is a complex systemic disease, the pathogens is not entirely clear. Airway and lung inflammation, oxidant/antioxidant imbalance and protease/antiprotease imbalance are considered to be main pathogenesis. This article makes a summary on the research progress of cytokines, mediators of inflammation, oxidative stress and protease/antiprotease imbalance in the pathogenesis of COPD.

作者张洋李永霞

机构地区昆明医科大学第二附属医院干疗二科

出处《昆明医科大学学报》 CAS 2015年第1期162-164,180,共4页 Journal of Kunming Medical University

基金国家自然科学基金资助项目(81460017)

关键词慢性阻塞性肺疾病细胞因子炎症介质氧化应激反应蛋白酶-抗蛋白酶失衡 Chronic obstructive pulmonary disease Cytokines Mediators of inflammation Oxidative stress Protease-antiprotease imbalance

分类号 R563.3 [医药卫生—呼吸系统]

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