摘要
他汀降低低密度脂蛋白胆固醇（LDL-C）可以显著减少动脉粥样硬化性心血管疾病（ASCVD）事件。分析6项他汀治疗冠心病患者血管内超声（IVUS）评价冠状动脉（冠脉）斑块体积变化的临床试验：他汀治疗后LDL-C显著降低到1.4-2.1mmol/L（53-79 mg/dl）冠脉斑块体积保持稳定,若同时升高载脂蛋白A1（ApoA1）〉9%（达到1.35-1.5g/L）和高密度脂蛋白胆固醇（HDL-C）〉8%（达到1.2-1.4mmol/L）（45-55mg/dl）,可以观察到冠脉斑块的逆转。这可以作为他汀类药物治疗减少胆固醇流入斑块和增加胆固醇流出斑块的目标值,对ASCVD防治具有重要指导意义。
Statins reduce atherosclerotic cardiovascular disease（ASCVD）events significantly by lowering low-density lipoprotein cholesterol（LDL-C）levels.We summarized six clinical trials in which intravascular ultrasound（IVUS）was used to assess change of coronary plaque volume in patients with coronary heart disease after statin therapy.The results showed that coronary plaque volume remained no progression when LDL-C level was reduced to 1.4-2.1mmol/L（53-79mg/dL）after statin treatment,while coronary atherosclerotic plaque regression was observed when apolipoprotein A1（Apo-A1）reached 1.35-1.5g/L（〉9% increase from baseline）and high-density lipoprotein（HDL-C）reached 1.2-1.4 mmol/L（45-55 mg/dL）（〉8% increase from baseline）.These data could be the optimal targets of statin therapy which effectively decrease cholesterol influx into plaque while increase cholesterol efflux from plaque,and have important implications for prevention and treatment of ASCVD.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2015年第1期1-5,共5页
Journal of Clinical Cardiology
