摘要
目的:用正交试验法优选肿痛涂膜剂的提取工艺,为其制备工艺、质量控制等提供理论依据。方法:以醇浸膏得率和大黄素、大黄酚总含量为考察指标,采用正交试验法对肿痛涂膜剂的提取工艺进行优化。结果:最佳醇提工艺为药材加70%乙醇提取2次,溶剂用量分别为10倍、8倍药材量,溶剂提取时间1.5 h、1 h。结论:经正交试验优选的肿痛涂膜剂的提取工艺简便、可靠、重复性佳,可为工业化生产提供理论依据。
Objective ：To optimize the extraction process of swelling-pain coating agent by orthogonal experiment, in order to provide the theoretical basis for preparation process and quality control etc. Methods：Taking the extraction rate of ethanol extract and the total contents of emodin and chrysophanol as the assessment indexes, the extraction process of swelling-pain coating agent was optimized by orthogonal experiment. Results：The optimium extraction process of ethanol was as follows：crude drugs plus 70% ethanol were extracted twice;the used solvent a- mounts were respectively 10,8 times of crude drugs volumes ;solvent extraction time is 1.5 h,1.0 h. Conclusion： The optimized extraction process of swelling-pain coating agent is simple, convenient and reliable, and has a good repeatability. It can provide the theoretical basis for industrialized production.
出处
《山西中医》
2015年第2期51-53,共3页
Shanxi Journal of Traditional Chinese Medicine
关键词
肿痛涂膜剂
正交试验
提取工艺
swelling-pain coating agent, orthogonal experiment, extraction process
