摘要
呼吸暂停是早产儿的常见病,在<1500 g早产儿发生率超过50%。对早产儿呼吸暂停(AOP)的治疗包括触觉刺激、经鼻持续气道正压通气(n CPAP)和呼吸兴奋性药物应用等。近年来甲基黄嘌呤类药物,尤其是咖啡因的使用已成为AOP的一线药物。咖啡因应用于早产儿除减少AOP,还能改善呼吸系统疾病和神经发育预后,减少支气管肺发育不良(BPD)的发生。
Apnea is a common problem in preterm infants and occurs in at least 50% of infants who are born with birth weight less than 1500 grams. Therapeutic approaches to apnea of prematurity （AOP） include tactile stimulation, nasal continuous positive airway pressure and pharmacological interventions. Recent advances in methylxanthine therapy, especially the introduction of Caffeine Citrate, have greatly improved the outcomes of AOP. Caffeine as a first line drug therapy for AOP also reduces the incidence of bronchial pulmonary dysplasia （BPD） and improves neurodevelopmental outcomes in preterm infants.
出处
《中国实用儿科杂志》
CSCD
北大核心
2015年第2期88-92,共5页
Chinese Journal of Practical Pediatrics
基金
科技部重大药物创新平台(2013ZX09303003)
"十二.五"支撑项目(2012BAI04B04)
