摘要
坏死性小肠结肠炎(NEC)是新生儿期的一种严重威胁患儿生命的疾病,也是新生儿重症监护室(NICU)最常见的胃肠道急症。随着极低出生体重儿成活率的不断增加,NEC的发病率亦在逐渐增多,且胎龄越小,发病率越高,病情越重。近年来,诸多研究发现,口服益生菌能够降低早产儿NEC的发病率以及减轻疾病的严重程度,但有关其预防NEC的确切机制尚未完全清楚。因此,本文将对益生菌预防新生儿NEC的有效性及安全性进行综述。
Necrotizing enterocolitis （NEC） is a serious disease which threats the lives of infants during the neonatal period and the most common gastrointestinal emergency of the neonate in the NICU. With the decrease mortality of VLBW, the incidence of NEC is gradually growing, and the smaller the gestatioual age, the higher the incidence, the more serious the disease. Recently, many studies have found that oral administration of probioties may reduce the incidence of NEC in the preterm babies and reduce the severity of the disease. However, the specific mechanisms of probioties in the prevention of NEC remain unclear. This article will review the efficacy and safety of the prevention of probiotics on the neonatal NEC.
出处
《中国实用儿科杂志》
CSCD
北大核心
2015年第2期112-115,共4页
Chinese Journal of Practical Pediatrics
关键词
益生菌
坏死性小肠结肠炎
预防
早产儿
probiotics
necrotizing enterocolitis
prevention
premature infants
