摘要
目的研究急性脑梗死(ACI)患者氧化低密度脂蛋白(Ox-LDL)与颈动脉内膜中层厚度(IMT)之间的关系。方法采用酶联免疫吸附测定(ELISA)检测44例ACI患者(ACI组)和30例健康者(对照组)血清Ox-LDL水平,并对ACI患者进行颈动脉超声检查,检测颈动脉IMT,分析ACI患者Ox-LDL水平与颈动脉IMT的关系。结果 ACI患者Ox-LDL水平明显高于健康者,差异有统计学意义(P<0.01);颈动脉IMT≥1.0mm的ACI患者Ox-LDL水平高于颈动脉IMT<1.0mm者(P<0.05);ACI患者Ox-LDL水平与颈动脉IMT呈正相关(r=0.493,P<0.05)。结论 ACI患者的血清Ox-LDL水平升高,与颈动脉粥样硬化密切相关。
Objective To study the relationship between the concentration of oxidized low density lipoprotein（Ox-LDL）and carotid intima-media thickness（IMT）in acute cerebral infarction（ACI group）.Methods 44 ACI patients（ACI group）and 30 healthy individuals（control group）were enrolled in the study,whose serum concentrations of Ox-LDL were determined by using enzymelinked immunosorbent assay（ELISA）,and carotid IMT of ACI patients were measured by using ultrasound,then the relationship between Ox-LDL and carotid IMT of ACI patients was analysed.Results The serum concentration of Ox-LDL in ACI group was significantly higher than that in control group（P〈0.01）.In ACI group,the serum concentration of Ox-LDL was positively correlated with carotid IMT（r=0.493,P〈0.05）.In ACI group,the serum Ox-LDL concentrations of patients whose IMT≥1.0were higher than patients whose IMT〈1.0mm（P〈0.05）.Ox-LDL concentrations of ACI patients were positively correlated with the carotid IMT（r=0.493,P〈0.05）.Conclusion The serum concentration of Ox-LDL increased significantly in ACI patients,and was closely related to carotid atherosclerosis.
出处
《国际检验医学杂志》
CAS
2015年第3期301-302,305,共3页
International Journal of Laboratory Medicine
关键词
急性脑梗死
氧化低密度脂蛋白
颈动脉内膜中层厚度
acute cerebral infarction
oxidized low density lipoprotein
intima-media thickness
