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可溶性ST2在心力衰竭中的临床应用前景 被引量：15

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摘要 ST2是白细胞介素1（interleukin-1,IL-1）受体超家族成员之一,有跨模型（ST2L）和可溶性（sST2）两种形式,一直以来被认为是一种孤儿受体,主要表达于Th2细胞、肥大细胞和成纤维细胞中,参与多种炎症过程并发挥免疫调节功能。2005年,IL-33作为ST2的特异性功能配体被发现[1],后来证实IL-33和ST2L结合具有心脏保护作用。
作者 王霞 张秀明
机构地区 中山大学附属中山医院检验科
出处 《国际检验医学杂志》 CAS 2015年第3期387-389,共3页 International Journal of Laboratory Medicine
关键词 可溶性ST2 心力衰竭 诊断 预后
分类号 R541.6 [医药卫生—心血管疾病] R446 [医药卫生—诊断学]
  • 相关文献

参考文献17

  • 1Schmitz J, Owyang A, Oldham E, et al. IL-33, an interleukin-1- like cytokine that signals via the IL-1 receptor-related protein ST2and induces T helper type 2-associated cytokines[J]. Immunity, 2005, 23(5) : 479-490.
  • 2Sanada S, Hakuno D, Higgins LJ,et al. IL- 33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling sys- tem[J]. J Clin Invest, 2007,117(15) : 1538-1549.
  • 3Tominaga S. A put ative protein of a growth specific cDNA from BALB-c3T3 cells is highly similar to the extracellular portion of mouse inter leukin 1 receptor[J]. FEBS Lett, 1989,258 (3) : 301- 304.
  • 4James L, Januzzi J. ST2 as a Cardiovascular Risk Biomarker: From the Bench to the Bedside J. of Cardiovasc[J]. Trans Res, 2013,6 (4) : 493-500.
  • 5Damien G, Thibault L, Sylvie AA, et al. Increased soluble ST2 is a stronger predictor of long-term cardiovascular death than natri- uretic peptides in heart failure patients with reduced ejection frac- tion[J]. Int J Cardiol,2014,172(1) :250-252.
  • 6Ciecone MM, Cortese F, Gesualdo M, et al. A novel cardiac bio- marker ST2 :a review[J]. Molecules, 2013,18 (12) : 15314-15328.
  • 7Wang YC,Yu CC,Chiu FC,et al. Soluble ST2 as a biomarker for detecting stable heart failure with a normal ejection fraction in hy- pertensive patients[J]. J Card Fail, 2013,19(3) : 163-168.
  • 8Januzzi JL Jr,Rehman S,Mueller T,et al. Importance of biomark- ers for long-term mortality prediction in acutely dyspneic patients [J]. Clin Chem,2010,56(12) :1814-1821.
  • 9Socrates T, defilippi C, Reichlin T, et al. Interleukin family member ST2 and mortality in acute dyspnoea[J]. J Intern Med, 2010, 268(5): 493-500.
  • 10Boisot S, Beede J, Isakson S, et al. Serial sampling of ST2 predicts 90-day mortality following destabilized heart failure Fail [J]. J Card Fail,2008,14(9) :732-738.

二级参考文献15

  • 1Rehman SU, Mueller T, Januzzi JL Jr. Characteristics of the novel interleukin family biomarker ST2 in patients with acute heart failure. J Am Coil Cardiol, 2008, 52: 1458-1465.
  • 2Bayes-Geins A,Pascual-Figal D, Januzzi JL, et al. Soluble ST2 mointoring provides additional risk stratification for outpatients with decompensated heart failure. Rev Esp Cardiol, 2010, 63: 1171-1178.
  • 3Weinberg EO, Shimpo M, De Keulenaer GW, et al. Expression and regulation of ST2, an interleukin-1 receptor family member, in eardiomyoeytes and myocardial infarction. Circulation, 2002, 106 : 2961-2966.
  • 4Chackerian AA,Oldham ER, Murphy EE, et al. IL-1 reeeptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol, 2007, 179 : 2551-2555.
  • 5Rakkar R,Lee RT. The IL-33/ST2 pathway: therapeutic target and novel biomarker. Nat Rev Drug Discov, 2008, 7: 827-840.
  • 6Miller AM, Liew FY. The 1L-33/ST2 pathway-A new therapeutic target in cardiovascular disease. Pharmacol Ther, 2011, 131 : 179-186.
  • 7Mueller T, Dieplinger B, Gegenhuber A, et al. Increased plasma concentrations of soluble ST2 are predictive for 1-year mortality in patients with acute destabilized heart failure. Clin Chem, 2008, 54 : 752-756.
  • 8Weir RAP, Miller AM, Murphy GE, et al. Serum soluble ST2 : a potential novel mediator in left ventricular and infarct remodeling after acute myocardial infarction. J Am Coil Cardiol, 2010, 55: 243 -250.
  • 9Bartunek J, Delrue L, Van Durme 17, et al. Nonmyocardial production of ST2 protein in human hypertrophy and failure is related to diastolic load. J Am Co11 Cardiol, 2008, 52: 21.66- 2174.
  • 10Takezako N, Hayakawa M, I-Iayakawa H, et al. ST2 suppresses IL-6 production via the inhibition of IkappaB degradation induced by the LPS signal in THP-1 cells. Biochem Biophys Res Commun, 2006, 341: 425-432.

共引文献32

同被引文献92

引证文献15

二级引证文献86

国际检验医学杂志
2015年 第3期

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