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多系统萎缩P型与帕金森病认知功能特点的临床研究 被引量：6

A cross-sectional study of cognitive performance in multiple system atrophy-parkinsonian variant and Parkinson's disease
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摘要 目的探讨多系统萎缩(MSA)-P型与帕金森病(PD)的临床特征和认知功能损害的异同。方法连续选择MSA-P型和PD患者共55例,根据诊断分为MSA-P组19例和PD组36例。详细收集年龄、病程、教育年限、统一PD评分量表第3部分(UPDRS-Ⅲ)及日常生活活动能力量表(ADL)评分等,用简易智能状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)、韦氏智力及记忆力等进行神经心理评估,并进行比较分析。结果 MSA-P组的ADL及UPDRS-Ⅲ评分均显著高于PD组[(31.74±10.56)分vs(16.39±4.18)分;(43.79±16.99)分vs(28.72±15.14)分,P<0.05]。2组MMSE、MoCA总分比较,无统计学差异[(26.32±3.13)分vs(27.50±2.52)分;(20.42±5.00)分vs(22.56±4.80)分,P>0.05]。MSA-P组操作量表分及韦氏记忆量表分低于PD组[(30.32±9.91)分vs(37.28±9.09)分;(54.53±23.14)分vs(76.28±22.97)分,P<0.05];图形排列、积木测试和理解记忆评分低于PD组[(5.79±2.12)分vs(7.22±1.69)分;(6.16±3.06)分vs(8.17±2.78)分;(5.53±2.74)分vs(7.75±2.99),P<0.05]。结论 MSA-P型患者运动功能及日常生活能力恶化较PD快;其总体认知功能受损与PD类似,但执行功能、视空间和记忆力等的认知损害较PD严重。 Objective To compare the cognitive functions of multiple system atrophy-parkinsonian variant （MSA P） and PD by studying their neuropsychological performances. Methods Fifty-five MSA P and PD patients were divided into MSA-P group （n=19） and PD group （n=36）. Their age,desease duration, education years, UPDRS -ⅢⅢ score, ADL score were recorded, their intelligence and memory were assessed according to the MMSE, MoCA scale, WAIS and WMS-R, and compared. Results The ADL and UPDRS HI scores were significantly higher in MSA P group than in PD group （31.74±10.56 vs 16.39±4.18,43.79±16.99 vs 28.72±15.14,P〈0.05）. No significant difference was found in MMSE and MoCA between the two groups （26.32±3. 13 vs 27.50±2.52,20.42±5.00 vs 22.56±4.80,P〉0.05）. The operation scale score,WMS-R score, block design score, picture arrangement score and logical memory score were significantly lower in MSA-P group than in PD group （P〈0.05）. Conclusion The motor function and daily life ability deteriorate faster in MSA-P patients than in PD patients. The general cognitive impairment is sim ilar in MSA P and PD patients. However,the impairment of executive function,visuospatial func tion and memory is more severe in MSA P patients than in PD patients.
作者 冯淑君 张玉虎 赵馨 聂坤 王丽敏 唐红梅 王丽娟
机构地区 南方医科大学研究生学院 广东省人民医院广东省医学科学院神经内科 广东省神经科学研究所
出处 《中华老年心脑血管病杂志》 CAS 2015年第2期150-153,共4页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金 国家自然科学基金(81371401 30801219) 广东省自然科学基金(S2013010014033) 广东省科技计划项目(2011B080701087) 广州市科技计划项目基金(2014J4100083 2013J4100068)
关键词 多系统萎缩 帕金森病 认知障碍 记忆 multiple system atrophy Parkinson disease cognition disorders memory
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献23

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二级参考文献26

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共引文献28

同被引文献50

  • 1郭起浩,洪震,吕传真,于欢,丁玎.Mattis痴呆评定量表(中文版)的效度分析[J].中国临床心理学杂志,2004,12(3):237-238. 被引量：21
  • 2张振馨.帕金森病的诊断[J].中华神经科杂志,2006,39(6):408-409. 被引量：617
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  • 10Tison F, Yekhlef F, Balestre E, et al. Application of the International Cooperative Ataxia Scale rating in multiple system atrophy[J]. Mov Disord, 2002, 17(6): 1248-1254.

引证文献6

二级引证文献7

中华老年心脑血管病杂志
2015年 第2期

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