摘要
目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)的病原菌分布和耐药性。方法收集柳州多家医院2012年2月至2014年6月期间呼吸内科的AECOPD患者805例,详细记录入组患者的临床资料,分析AECOPD患者的病原菌分布及耐药特点。结果 805例AECOPD患者中分离出病原菌482例,共分离病原菌602株,其中革兰氏阴性菌430株,占71.5%,革兰氏阳性菌97株,占16.1%,真菌75株,占12.5%;铜绿假单胞菌、肺炎克雷伯菌、大肠埃希菌居前3位,分别占20.3%、18.3%和13.8%;肺炎克雷伯菌和大肠埃希菌对哌拉西林耐药率均>80.0%,大肠埃希菌对头孢哌酮、头孢曲松、环丙沙星、左氧氟沙星耐药率较高,均>50.0%。结论 AECOPD病原菌以革兰阴性杆菌为主,治疗应根据病原菌及药敏试验结果指导,临床合理选用抗菌药物。
Objective To discuss the pathogenic bacteria distribution and drug resistance in AECOPD pa-tients. Methods The clinical data of 805 AECOPD patients were reviewed to analyze their pathogenic bacteria distribution and drug resistance characteristics. Results 482 cases of pathogenic bacteria were isolated, which ob-tained 602 strains of pathogenic bacteria. There were 97 strains of gram-positive bacteria （16. 1%）, 430 strains of gram-negative bacteria （71. 5%） and 75 strains of fungus （12. 5%）. The most bacteria was pseudomonas aerugino-sa, followed by klebsiella pneumoniae and escherichia coli （20. 3%, 18. 3% and 20. 3% respectively）. Klebsiella pneumoniae and escherichia coli were highly resistant to piperacillin （ 〉80. 0%） , Escherichia coli was highly resist-ant to cefoperazone, ceftriaxone, ciprofloxacin, levofloxacin （ 〉50. 0%） . Conclusion The main pathogen of AE-COPD is gram-negative bacilli, and the anti-biotics should be rationally chosen based on drug sensitivity test results.
出处
《临床肺科杂志》
2015年第3期446-449,共4页
Journal of Clinical Pulmonary Medicine
基金
广西壮族自治区卫生厅科研课题(No Z2012605)
