摘要
目的探讨乳腺浸润性导管癌中雌激素调节蛋白(PS2)的表达及其与雌激素受体(ER)、孕激素受体(PR)的关系。方法收集新疆医科大学附属肿瘤医院2008-2009年经病理确诊并行外科手术治疗的70例乳腺浸润性导管癌组织石蜡标本,采用免疫组化法检测PS2、ER、PR表达,分析PS2与ER、PR表达及临床病理因素的相关关系。结果 PS2、ER、PR阳性表达率分别为37.14%(26/70)、40.00%(28/70)、42.86%(30/70)。PS2在ER阳性和阴性病例中的阳性表达率分别为60.71%(17/28)和21.43%(9/42),两者差异有统计学意义(P<0.05)。PS2在PR阳性和阴性病例中的阳性表达率分别为66.67%(20/30)和15.00%(6/40),两者差异有统计学意义(P<0.05)。患者年龄、月经状态与PS2蛋白表达无明显关系(P>0.05),PS2表达与ER呈正相关(γs=0.35,P=0.014),PS2表达与PR呈正相关(γs=0.475,P=0.000),PS2表达与患者组织分级及淋巴结转移有关(P<0.05)。结论 PS2表达与ER、PR及淋巴结转移状况与组织分级临床因素有关。ER、PR、PS2综合检测对判定乳腺内分泌治疗效果及预后具有重要意义。
Objective To study the expression of PS2 and the clinical correlation between PS2 and ER, PR in patients with breast infiltrating ductal carcinoma. Methods Detect the expression of PS2, ER and PR in 70 cases of samples in patients with breast infiltrating ductal carcinoma by using immunohistochemical method. The clinical relevance of the PS2 with ER, PR and clinical factors were analyzed. Results The positive rates of PS2, ER, PR were 37.14% （26/70）, 40.0% （28/70）, 42.86% （30/70） respectively. The positive expression rate of PS2 was 60.71%（17/28） for the ER positive group and 21.43%（9/42） for the ER negative group. There were significant differences （P 〈0.05）. The positive rate of PS2 protein in PR positive group and negative group were 66.67% （20/30） and 15.00% （6/40） respectively. The menstrual status and age of patients had no significant effects on the PS2 protein expression （P〉0.05）. The expres- sion of PS2 protein could be affected by the clinical stages and lymphatic metastasis （P 〈0.05） . Conclusion The expression of PS2 in breast infiltrating ductal carcinoma was significantly correlated with ER, PR and the pathological factors such as clinical stages and lymph node metastasis status. The comprehensive test of ER, PR, PS2 had great significance in determining the effect of endocrine treatment and prognosis of breast cancer.
出处
《新疆医科大学学报》
CAS
2015年第3期341-343,349,共4页
Journal of Xinjiang Medical University
基金
新疆医科大学科研创新基金(XJC201270)
