摘要
目的比较巴曲酶与地塞米松治疗中高频下降突发性耳聋的效果。方法选取2011年3月~2013年11月在本院耳鼻咽喉科就诊并且确诊为中高频下降突发性耳聋患者114例,采用随机数字表法将患者分为两组,各57例。两组均给予基础治疗,观察组在此基础上加用蛋白酶类药物巴曲酶治疗,对照组加用糖皮质激素类药物地塞米松治疗。比较两组的治疗效果及不良反应发生率。结果观察组的总有效率、痊愈率和显效率均高于对照组,且其显效率（χ^2=7.255,P=0.007）和总有效率（χ^2=12.120,P=0.000）差异均有统计学意义。观察组的不良反应发生率为7.0%,显著低于对照组的22.8%,差异有统计学意义（χ^2=5.600,P=0.018）。结论巴曲酶治疗中高频下降突发性耳聋的效果好,不良反应少,临床上推荐在常规治疗的基础上静脉使用巴曲酶。
Objective To compare the effect of batroxobin and dexamethasone treating sudden deafness of medium-high frequency decline. Methods 114 patients sudden deafness of medium-high frequency decline treated and diagnosed in department of ear-nose-throat of our hospital from March 2011 to November 2013 were selected and were randomly divided into the two groups,and there were 57 cases in each group.The patients in the two groups were firstly given basic treatment,and then the patients in the observation group were treated with batroxobin（a kind of protease drugs） on the basis of the basic treatment,while the patients in the control group were treated with dexamethasone（a kind of glucocorticoid drugs） on the basis of the basic treatment.The treatment effect and the incidence rate of adverse reaction of the two groups were compared. Results The total effective rate,the cure rate and markedly effective rate of observation group was higher than those of control group,and its total effective rate（χ^2=12.120, P =0.000）,markedly effective rate（χ^2=7.255, P=0.007） had statistical difference.The incidence rate of adverse reaction in the observation group（7.0%） was obviously lower than that in the control group（22.8%）,and there was a statistical difference of the two groups（χ^2=5.600,P =0.018）. Conclusion Batroxobin treating sudden deafness of medium-high frequency decline has good effect with fewer adverse reaction.Batroxobin for ntravenous use is clinically recommended on the basis of routine therapy.
出处
《中国当代医药》
2015年第3期122-124,共3页
China Modern Medicine
关键词
巴曲酶
地塞米松
中高频下降
突发性耳聋
Batroxobin
Dexamethasone
Medium-high frequency decline
Sudden deafness
