摘要
目的探讨年龄在50岁以下的停经与未停经的女性冠状动脉粥样硬化性心脏病(冠心病)患者的危险因素、临床及冠状动脉造影特点。方法选取经临床及冠状动脉造影确诊的年龄50岁以下女性冠心病住院患者共173例,按月经情况分为停经组与未停经组,对比分析两组间冠心病危险因素、临床及冠状动脉造影特点。结果未停经组年龄小于停经组,差异有统计学意义[(44.5±5.6)岁vs.(48.4±2.1)岁,P<0.05];两组体质量比较,差异无统计学意义(P>0.05)。未停经组血脂异常及糖尿病患者比例明显多于停经组,差异有统计学意义(15.0%vs.0,P<0.05;62.1%vs.42.4,P<0.05);空腹血糖浓度高于停经组,差异有统计学意义[(6.27±2.30)mmol/L vs.(5.40±0.90)mmol/L,P<0.05]。未停经组高密度脂蛋白浓度低于停经组,差异有统计学意义[(1.21±0.31)mmol/L vs.(1.02±0.28)mmol/L,P<0.05],而两组其他血脂成分(血清总胆固醇、低密度脂蛋白、三酰甘油、载脂蛋白A及载脂蛋白B100浓度)比较,差异均无统计学意义(P>0.05)。两组尿蛋白阳性患者比例、血清尿酸及血清肌酐浓度比较,差异无统计学意义(P>0.05)。未停经组患者左前降支及其分支受累率明显高于停经组,差异有统计学意义(76.4%vs.51.5%,P<0.05);发生急性心肌梗死的患者比例也比停经组高,差异有统计学意义(26.4%vs.6.1%,P<0.05)。结论年龄50岁以下女性冠心病患者,未停经患者比停经患者年轻,有血脂异常及糖尿病等冠心病危险因素的患者比已停经患者多。未停经患者比已停经年轻女性冠心病患者高危,需要及时识别并积极诊治。
Objectives To investigate the risk factors,clinical and angiographic features in women with coronary artery disease（CAD） aged under 50 before and after menopause. Methods One hundred and seventy-three women with CAD aged under 50 were included and classified as pre-menopause group and post-menopause group. Differences in CAD risk factors,clinical and angiographic features between the two groups were analyzed. Results Patients in pre-menopause group were significantly younger than those in post-menopause group [（44.5±5.6） years vs.（48.4±2.1） years,P〈0.05 ],while with similar body weights（P〉0.05）. There were much more patients with diabetes and dyslipidemia in premenopause group than in post-menopause group（15.0% vs. 0,P〈0.05; 62.1% vs. 42.4,P〈0.05） and serum glucose in pre-menopause group was significantly higher than that in post-menopause group [（6.27±2.30） mmol / L vs.（5.40±0.90）mmol / L,P〈0.05 ]. Serum concentration of high-density lipoprotein（HDL） was significantly lower in pre-menopause group than in post-menopause group [（1.21±0.31） mmol / L vs.（1.02±0.28） mmol / L,P〈0.05 ],while no significant difference as for other blood lipid components（total cholesterol,low-density lipoprotein,triglycerides,apolipoprotein A and apolipoprotein B100） was found between the two groups（all P〉0.05）. Percentage of patients with positive urine protein value,urine and serum creatinine were similar between the two groups（P〉0.05）. There were much more patients with diseased left anterior descending artery and suffered from acute myocardial infarction in pre-menopause group than in post-menopause group（76.4% vs. 51.5%,P〈0.05; 26.4% vs. 6.1%,P〈0.05）. Conclusions Of female patients with CAD aged under 50,those who remain pre-menopausal are younger and with more CAD risk factors such as diabetes and dyslipidemia. These high-risk patients need to be screened and treated aggressively in the early stage.
出处
《岭南心血管病杂志》
2015年第1期43-46,共4页
South China Journal of Cardiovascular Diseases
关键词
冠状动脉疾病
冠状动脉造影
危险因素
停经
女性
coronary heart disease
coronary angiography
risk factors
menopause
female
