摘要
目的探讨低剂量米索前列醇（misoprostol）经阴道给药方式,用于Bishop宫颈成熟度评分值低（low-Bishop-score）（〈6分）孕妇引产的疗效及护理成效。方法选择2012年4~10月在崇州市妇幼保健院住院分娩的100例年龄为21~36岁的Bishop宫颈成熟度评分值低（〈6分）待产孕妇为研究对象。按照抽签法将其随机分为米索前列醇组（n=60,采用低剂量米索前列醇经阴道给药引产）与缩宫素组（n=40,采用缩宫素引产）,比较两组产妇的引产效果、安全性、新生儿情况、阴道分娩率及优质护理满意度。本研究遵循的程序符合崇州市妇幼保健院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象本人的知情同意,并与之签署临床研究知情同意书。两组患者年龄、分娩孕龄、Bishop宫颈成熟度评分值及妊娠合并症等临床资料比较,差异均无统计学意义（P〉0.05）。结果米索前列醇组引产成功率显著高于缩宫素组,并且差异有统计学意义（P〈0.05）。米索前列醇组自用药到宫缩发动时间及第一产程时间均显著短于缩宫素组,产后2h出血量显著少于缩宫素组,经阴道分娩率显著高于缩宫素组,并且差异均有统计学意义（P〈0.05）。米索前列醇组患者的护理满意率显著高于缩宫素组,而且差异亦有统计学意义（P〈0.05）。结论对于Bishop宫颈成熟度评分值低孕妇采用低剂量米索前列醇经阴道给药引产的方法安全、有效,相对于缩宫素引产,可提高经阴道分娩率,而且护理成效显著。
Objective To study the curative effects and nursing effects of low-dose vaginal misoprostol for labor induction with low-Bishop-score（〈 6 score）pregnancy. Methods From April to October 2012, a total of 100 cases pregnant women who delivered in Chongzhou Maternal ＆ Child Health Hospital were selected into this study. Their ages were 21-36 years old, with low-Bishop-score （〈6 score）. According to strategies of labor induction by a lottery, they were divided into misoprostol group （n = 60, labor induction with low-dose vaginal misoprostol） and oxytocin group （n = 40, labor induction with intravenous oxytocin）. Effects of labor induction, safety, outcomes of newborn, vaginal delivery rate and quality of nursing satisfaction were statistically analyzed between two groups. The study protocol was approved by the Ethical Review Board of Investigation in Chongzhou Maternal ＆ Child Health Hospital. Informed consent was obtained from each participate. There were no significant differences of age, gestational age,Bishop-score, and etc. between two groups （P〉0. 05）. Results The successful rate of labor induction in misoprostol group was much higher than that in oxytocin group, and with significant differences （P〈0.05）. Duration from use of low-dose vaginal misoprostol/ intravenous of oxytocin, and the first stage of labor in misoprostol group were much shorter than those in oxytocin group, and with significant difference （P〈0. 05）. Rate of satisfaction with nursing care in misoprostol group was much better than that in oxytocin group , and also with significant difference （P〈0.05）. Conclusions It is safeand effective for labor induction with low-dose vaginal misoprostol to low Bishop-score pregnancy. Compared with intravenous oxytoein low-dose vaginal misprostol can increase the rate of vaginal delivery, and quality of satisfaction with nursing care is excellent.
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2015年第1期35-38,共4页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
基金
四川省基层卫生事业发展研究中心项目(SGWF1415)~~
