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异甘草酸镁与多烯磷脂酰胆碱联合应用治疗胆道梗阻性肝损害

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摘要 目的:探讨联合应用异甘草酸镁和多烯磷脂酰胆碱治疗胆道梗阻性肝损害的效果。方法128例梗阻性黄疸患者分为治疗组(n=68)和对照组(n=60)。围手术期保肝治疗方案为:治疗组联合使用异甘草酸镁和多烯磷脂酰胆碱,对照组单独应用异甘草酸镁。观察手术前后血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和总胆红素(TBIL)的变化。结果两组ALT、AST于入院当天、术前1 d及术后1 d比较差异无统计学意义(P>0.05);术后1、3、7 d两组ALT、AST皆逐步下降;组间比较,术后1 d ALT、AST差异无统计学意义(P>0.05),术后3、7 d治疗组ALT、AST显著低于对照组(P<0.05)。术后1、3 d两组TBIL较术前皆出现显著下降,但组间比较差异无统计学意义(P>0.05);术后7 d治疗组TBIL显著低于对照组(P<0.05)。治疗期间2组患者均未出现明显药物不良反应。结论对于梗阻性黄疸患者围手术期药物保肝治疗,联合运用异甘草酸镁和多烯磷酯酰胆碱较单独应用异甘草酸镁具有更好的疗效。
出处 《中国血液流变学杂志》 CAS 2014年第2期272-273,共2页 Chinese Journal of Hemorheology
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  • 1巩鹏,王忠裕,宝全.胆道梗阻后心脏损害的研究[J].肝胆外科杂志,2003,11(6):465-467. 被引量:9
  • 2Stelios F Assimakopoulos,Constantine E Vagianos,Aristides S Charonis,Ilias H Alexandris,Iris Spiliopoulou,Konstantinos C Thomopoulos,Vassiliki N Nikolopoulou,Chrisoula D Scopa.Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: Effect of bombesin and neurotensin[J].World Journal of Gastroenterology,2006,12(21):3410-3415. 被引量:22
  • 3Adachi M,Ishii H.Role of mitochondria in alcoholic liver injury.Free Radic Biol Med,2002,32:487-491.
  • 4Mak KM,Wen KF,Ren CL,et al.Dilinoleoylphosphatidylcholine reproduces the antiapoptotic actions of polyenylphosphatidylcholine against ethanol-induced hepatocyte apoptosis.Alcohol Clin Exp Res,2003,27:997-1005.
  • 5Navder KP,Lieber CS.Dilinoleoylphosphatidylcholine is responsible for the beneficial effects of polyenylphosphatidylcholine on ethanol-induced mitochondrial injury in rats.Biochem Biophys Res Commun,2002,291:1109-1112.
  • 6Katz GG,Shear NH,Malkiewicz IM,et al.Signaling for ethanol-induced apoptosis and repair in vitro.Clin Biochem,2001,34:219-227.
  • 7Cao Q,Mak KM,Lieber CS.Dilinoleoylphosphatidylcholine prevents transforming growth factor-β1-mediated collagen accumulation in cultured rat hepatic stellate cells.J Lab Clin Med,2002,139:202-210.
  • 8Cao Q,Mak KM,Lieber CS.DLPC decreases TGFβ1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells.Am J Physiol Gastrointest Liver Physiol,2002,283:G1051-G1061.
  • 9Lieber CS.Pathogenesis and treatment of alcoholic liver disease:progress over the last 50 years.Rocz Akad Med Bialymst,2005,50:7-20.
  • 10Lieber CS.Alcoholic fatty liver:its pathogenesis and mechanism of progression to inflammation and fibrosis.Alcohol,2004,34:9-19.

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