摘要
目的:采用流化床混悬液上药法制备非诺贝特速释微丸。方法:以上药效率、脆碎度、粘连率为评价指标,考察并优化混悬液上药法制备非诺贝特速释微丸的处方。结果:确定FNBT/HPMC-E5/SDS=160∶20∶1.6为最佳配比处方,选定固含量为20%,上药效率为95%,溶出度为15 min达90%。结论:流化床混悬液上药法制备非诺贝特微丸,上药效率高,方法简便可靠,溶出迅速。
Objective: To prepare immediate-release pellets of fenofibrate by suspension layering.Methods: Drug-Loading efficacy, friability and agglomerates were selected as main indexes to evaluate and optimize the formulation of fenofibrate pellets prepared by suspension layering. Results: The optimized formulation was as follows: FNBT/HPMC-E5/SDS=160∶20∶1.6, solid content was 17.5%, drug-loading efficacy was about 95%, 15 min dissolution was about 90%. Conclusion: Suspension layering can prepar pellets with high drug-loading efficacy, acceptable friability and fast dissolution.
出处
《药学与临床研究》
2015年第1期23-26,共4页
Pharmaceutical and Clinical Research
关键词
非诺贝特
速释微丸
混悬液上药法
Fenofibrate
Immediate-release pellet
Suspension layering
