摘要
固体分散体在提高难溶性药物溶出度和口服生物利用度中的应用引起了药学工作者的关注,本文综述了固体分散体常用载体、常用的溶剂、提高难溶性药物溶出速率的机制和制备方法以及其他替代的方法,以期将难溶性药物制备为固体分散体提供参考。
Solid dispersion have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. This article reviews the commonly used carriers and solvents, the mechanisms for improving drug release rates, various preparation techniques and alternative strategies as the references, for poorly water-soluble drugs to be prepares into solid dispersions.
出处
《药学与临床研究》
2015年第1期51-54,共4页
Pharmaceutical and Clinical Research
关键词
固体分散体
难溶性药物
生物利用度
Solid dispersion
Poorly water-soluble drugs
Bioavailability
