摘要
目的探讨妊娠高血压孕妇外周血抗磷脂抗体(ACA)水平与不良妊娠结局的相关性。方法仅ACA阳性的妊娠高血压孕妇50例归入观察A组,仅抗β2-糖蛋白1(β2-GP1)抗体阳性孕妇50例归入观察B组,ACA及抗β2-GP1抗体均阴性孕妇50例归入对照组。比较3组孕妇妊娠不良结局出现率。以观察A组和观察B组孕妇为研究对象,分析ACA-Ig M、ACA-Ig G、抗β2-GP1抗体与胎儿宫内发育迟缓(FGR)、围产儿死亡、早产等主要不良妊娠结局的相关性。结果观察A组和观察B组不良妊娠结局出现率均显著高于对照组(P<0.05)。ACA-Ig M与FGR呈显著正相关性(P<0.05),ACA-Ig G、ACA-Ig M及抗β2-GP1抗体水平均与早产呈现正相关性(P<0.05),抗β2-GP1抗体与围产儿死亡呈正相关性(P<0.05)。结论妊娠高血压孕妇ACA水平与不良妊娠结局存在一定相关性。
Objective To explore the correlation between anticardiolipin antibody（ ACA）level and pregnancy outcomes in pregnant women with gestational hypertension. Methods Fifty pregnant women with gestational hypertension diagnosed as positive ACA were selected as observation group A,50 pregnant women with gestational hypertension diagnosed as positive beta 2-resistant GP1（ β2-GP1） antibody were selected as observation group B,and 50 pregnant women diagnosed as negative ACA and β2-GP1 antibody were selected as control group. Incidence rate of adverse pregnancy outcomes was compared in three groups. Patients in the observation group A and B were considered as the research object,and correlations between ACA- Ig M,ACA,β2-GP1 antibody and fetal retardation（ FGR）,prenatal death,premature birth were analyzed. Results Incidence rate of adverse pregnancy outcomes in the observation group A and the observation group B was significant higher than that in the control group（ P〈0. 05）. ACA-Ig M was positively correlated with FGR（ P〈0.05）,levels of ACA-Ig M,ACA and β2-GP1 antibody were positively correlated with premature birth（ P〈0. 05）,and β2-GP1 antibody was positively correlated with the prenatal death（ P〈0. 05）.Conclusion In the patients with gestational hypertension,ACA level is correlated with adverse pregnancy outcomes.
出处
《实用临床医药杂志》
CAS
2015年第3期95-97,共3页
Journal of Clinical Medicine in Practice
关键词
妊娠高血压
抗磷脂抗体
抗β2-糖蛋白抗体
不良妊娠结局
gestational hypertension
anticardiolipin antibody
beta 2-GPI antibody
adverse pregnancy outcomes
