摘要
目的研究MCM7和P53在食管癌组织中的表达及与临床病理参数间的关系。方法采用免疫组织化学(S-P)法检测了80例食管癌标本及30例正常食管组织中MCM7和P53的表达,其中鳞癌60例,腺癌20例。结果 MCM7蛋白在食管癌组织中的表达显著高于正常组织,在肿瘤分化程度、临床分期、浸润深度、有无淋巴结转移的分组间比较,差异有统计学意义(P<0.05),而与病理类型无关(P>0.05)。P53蛋白在食管癌组织中的表达显著高于正常组织,在肿瘤分化程度、临床分期、浸润深度、有无淋巴结转移的分组间比较,差异有统计学意义(P<0.05),而与病理类型无关(P>0.05)。结论 MCM7和P53蛋白的联合检测可作为食管癌早期诊断和判断预后的一个生物学指标。
Objective To research the relationship between the expression and the clinicopathological parameters of the MCM7 and P53 in esophageal tissue. Methods Detected the expression of the MCM7 and P53 in 80 cases of esophageal carcinoma and 30 cases of normal esophageal tissues using immunohistochemistry （S-P） Act, In which 60 cases of squamous cell carcinoma, 20 cases of adenocarcinoma. Results MCM7 protein expression in esophageal cancer was significantly higher than in normal tissue, comparison between groups of the degree of tumor differentiation, clinical stage, depth of invasion, lymph node metastasis, the difference was statistically significant （P〈0.05）, but nothing to do with the pathological type （P〉0.05）. P53 protein expression in esophageal cancer was significantly higher than in normal tissue, comparison between groups of the degree of tumor differentiation, clinical stage, depth of invasion, lymph node metastasis, the difference was statistically signiifcant （P〉0.05）, but nothing to do with the pathological type （P〉0.05）. Conclusion The combined detection of MCM7 and P53 protein can be used as a biological indicator of esophageal cancer early diagnosis and prognosis.
出处
《中国继续医学教育》
2015年第4期173-175,共3页
China Continuing Medical Education
