摘要
目的：调查影响非小细胞肺癌患者高凝状态的临床相关因素。方法：对2011年3月至2012年11月入住北京军区总医院肿瘤科的195例非小细胞肺癌患者的高凝状态特征进行调查,并分析其与临床相关因素如年龄、性别、病理特征、ECOG评分、中心静脉置管、化疗、放疗、临床分期和合并疾病的关系。结果：195例NSCLC患者中,170例（87%）出现不同程度的凝血指标异常,42例（21.5%）出现PLT升高,78例（40%）出现FIB升高,12例（6.2%）出现TT延长,45例出现（23.1%）PT缩短,60例出现（30.8%）D-D升高,15例出现（7.7%）APTT缩短。NSCLC患者的高凝状态与其年龄、放疗、中心静脉置管均无关（P〉0.05）。而男性TT值显著高于女性,腺癌NSCLC患者FIB值显著高于鳞癌和其它类型NSCLC患者,ECOG≤2的NSCLC患者PT、FIB的水平显著高于ECOG〉2者,接受化疗的NSCLC患者APTT、PT水平均显著低于未化疗者,Ⅲ~Ⅳ期NSCLC患者FIB水平显著高于Ⅰ~Ⅱ期NSCLC患者,合并其它疾病的NSCLC患者TT、PT水平均显著低于无合并疾病者（P〈0.05）。结论：NSCLC患者易发生高凝状态,可能与其性别、病理类型、ECOG评分、化疗、临床分期及合并疾病有关,如何进行抗凝治疗以改善患者的生存质量还需要进一步研究。
Objective： To investigate the clinical characteristics and influencing factors of non-small cell lung cancer with hyper- coagulability. Methods： A total of 195 cases of non-small cell lung cancer patients with hypercoagulability admitted in Beijing Military Region Oncology from March 2011 and Nov 2012 were investigated and the relationship between clinical factors, including age, gender, pathological, ECOG performance, central venous catheters, chemotherapy, radiotherapy, clinical stage as well as merger disease, and hy- percoagulability of non-small cell lung cancer patients were analyzed. Results： Among 195 non small cell lung cancer patients, 170 （85%） cases had abnormal hypercoagulabe indicators, PLT elevated were found in 42 patients （21.5%）, FIB increased in 78 cases （40%）, TT extended in 12 cases （6.2%）, PT shortened in 45 cases （23.1%） again, D-D increased in 60 cases （30.8%）, and APTT reduced in 15 cases （7.7%）. No significant difference was observed among the age, radiotherapy, central venous catheters and hypercoagulable state of NSCLC patients （P〉0.05）. But the male group had higher level of TT than female group, the Adenocarcinoma group had higher level of FIB than Squamous and others group, ECOG〈 2 group had higher level of PT and FIB than ECOG〉2 groups,the level of APTT and PT of Chemotherapy group were lower than those of non-chemotherapy group, stage Ⅲ -ⅣV had higher levels of FIB than those in stage Ⅰ-Ⅱ NSCLC patients, the TT, PT levels of non-complications group were lower than those of each complications group （P〈0.05）. Conclusion：Patients with NSCLC were susceptible to hypercoagulative state, which may be related with the gender, ECOG performance, chemotherapy, clinical stage and merger disease. How to use the anticoagulant therapy and improve the quality of life of NSCLC should be further researched.
出处
《现代生物医学进展》
CAS
2015年第5期882-886,877,共6页
Progress in Modern Biomedicine
基金
首都医学发展科研基金(首发基金联合攻关项目)(SF-2009-Ⅰ-14)
关键词
非小细胞肺癌
高凝状态
静脉血栓
Non-small cell lung cancer
Hypercoagulability
Venous thrombosis
