摘要
聚癸二酸甘油酯(PGS)是一种生物可降解的高分子聚合弹性体,因其良好的性能,在许多生物医学研究中应用广泛。PGS支架的机械性能与机体软组织相似,依从性好,降解时以表面侵蚀的方式降解,不伴有膨胀或变形,周围组织炎症反应、纤维变性轻,与多种细胞相容性好。基于PGS良好的性能,主要应用于软组织替代和软组织工程,比如心肌、血管、神经、软骨、视网膜、鼓膜,另外也有用于药物转运载体、组织粘附材料的研究。
Poly（glycerol sebacate） （PGS） is a biodegradable polymer increasingly used in a variety of biomedical applications be- cause of its good performance. PGS is an elastomeric polymer with mechanical properties similar to human tissues, which allows mechani- cal compliance with tissue and enables facile surgical handling of the polymer. Especially important for the present application, PGS de- grades through a surface erosion process that results in loss of mass with no detectable swelling or change in the geometry of the bulk polymer. Recent studies demonstrate the in vitro biocompatibility of PGS with 3T3 human fibroblasts, baboon primary endothelial pro- genitor cells and smooth muscle cells, rat Schwann cells, and mouse retinal progenitor cells. In vivo studies have shown that PGS causes less inflammation and fibrosis than poly （lactide-co-glycolide）, a well-studied and widely used biomaterial, and in contrast to poly（lac- tide-co-glycolide）, PGS does not induce a foreign body giant cell response.
出处
《现代生物医学进展》
CAS
2015年第5期976-981,共6页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(31040033)
黑龙江省自然科学基金项目(D201081)
关键词
组织工程支架
聚癸二酸甘油酯
生物相容性
Tissue engineering scaffold
Poly （glycerol-sebacate）
biocompatibility
