摘要
目的观察坎地沙坦联合贝那普利治疗糖尿病肾病并高血压的疗效。方法糖尿病肾病并高血压患者84例,随机分为坎地沙坦组、贝那普利组及联合用药组,每组28例。坎地沙坦组患者给予坎地沙坦8 mg·d-1,贝那普利组给予贝那普利10 mg·d-1,联合用药组给予坎地沙坦8 mg·d-1和贝那普利10 mg·d-1进行治疗。治疗16周后,比较各组治疗前后血压、血清肌酐(SCr)、尿素氮(BUN)、24 h尿蛋白、血钾等指标的变化。结果治疗16周后,3组患者收缩压、舒张压均较治疗前显著下降(P<0.05),且联合用药组患者收缩压、舒张压水平均低于坎地沙坦组和贝那普利组(P<0.05)。与治疗前比较,3组患者的SCr、BUN及24 h尿蛋白水平均显著下降(P<0.05),且联合用药组SCr、BUN和24 h尿蛋白水平较坎地沙坦组和贝那普利组显著降低(P<0.05)。3组患者治疗前后血钾水平无明显变化(P>0.05)。治疗过程中各组未见明显不良反应。结论坎地沙坦联合贝那普利治疗糖尿病肾病并高血压可明显降低患者血压及尿蛋白水平,改善患者肾功能,临床应用疗效显著,较单药治疗效果佳。
Objective To investigate the efficacy of candesartan combined with benazepril in the treatment of diabetic nephropathy with hypertension patients.Methods Eighty-four patients with diabetic nephropathy with hypertension were randomly divided into candesartan group,benazepril group and drug combination group,with 28 cases in each group.The three groups were given candesartan 8 mg·d^-1,benazepril 10 mg·d^-1and both the two drugs at the same dose respectively.After16 weeks＇ treatment,blood pressure,serum creatinine（SCr）,blood urea nitrogen（BUN）,24-hour urinary protein and serum potassium were determined and compared among the groups.Results Sixteen weeks after treatment,the systolic pressure and diastolic pressure decreased significantly in the three groups compared with those before treatment（P 〈0.05）,which decreased significantly in drug combination group than those in candesartan group and benazepril group（P 〈0.05）.The levels of SCr,BNU and 24-hour urinary protein significantly decreased than those before treatment（P 〈0.05）,which decreased significantly in drug combination group compared with those in candesartan group and benazepril group（P 〈0.05）.There was no significant difference of serum potassium level between before treatment and after treatment in the three groups（P 〉0.05）.No adverse reactions was found during treatment.Conclusion Candesartan combined with benazepril can significantly decrease both blood pressure and 24-hour urinary protein level in diabetic nephropathy with hypertension patients,and improve their renal function,which has evident effect and better than single drug treatment.
出处
《新乡医学院学报》
CAS
2015年第1期65-67,共3页
Journal of Xinxiang Medical University
关键词
糖尿病肾病
高血压
坎地沙坦
贝那普利
diabetic nephropathy
hypertension
candesartan
benazepril
